A mechanism of development of arterial thrombosis: β2-glycoprotein I-specific ligand and autoantibody
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- LIU Qingping
- Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry
Bibliographic Information
- Other Title
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- 抗リン脂質抗体症候群における動脈血栓の発症機序:β2-グリコプロテインIに特異的なリガンドと自己抗体の関与
- A mechanism of development of arterial thrombosis: β2-glycoprotein I-specific ligand and autoantibody
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Abstract
β2-Glycoprotein I (β2-GPI) is a major antigen for anticardiolipin antibodies (aCL) appeared in patients with antiphospholipid syndrome (APS). We recently reported that β2-GPI specifically binds to oxidized low-density lipoprotein (oxLDL) and that on of the β2-GPI's major ligands derived from oxLDL, oxLig-1, is 9-(7-ketocholest-5-en-3β-yloxy)-9-oxononanoic acid (J. Lipid Res. 42, 697, 2001). In the present study, it was demonstrated that carboxylated variants of cholesteryl linoleate have a critical role for β2-GPI binding. In vitro experiments indicate that oxLDL was uptaken by macrophages via an interaction among the ligand such as oxLig-1, β2-GPI, and anti-β2-GPI autoantibodies. The uptake was not occurred by cholesterol or its ester without a free carboxyl residue, i.e., cholesteryl lenoleate, by cholesterol, or by 7-ketocholesterol alone, even in the presence of β2-GPI and anti-β2-GPI antibodies. Thus, carboxyl variants of cholesteryl ester specific for β2-GPI may mediate anti-β2-GPI Ab-dependent uptake of oxLDL by macrophages and autoimmune atherogenesis developed in APS.
Journal
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- Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
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Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 114 (1), 39-51, 2002
Okayama Medical Association
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Keywords
Details 詳細情報について
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- CRID
- 1390001204876577664
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- NII Article ID
- 10012336781
- 130006858033
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- NII Book ID
- AN00032489
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- ISSN
- 18824528
- 00301558
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- Data Source
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed