原発性胆汁性肝硬変肝組織におけるFas発現の免疫組織化学的検討

• 貴志 文俊

  Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry

書誌事項

タイトル別名

• Immunohistochemical Study of Fas in Primary Biliary Cirrhosis

抄録

The expression of Fas on the epithelial cells of bile ducts was examined in liver specimens from 10 patients with primary biliary cirrhosis (PBC), and 14 patients with chronic hepatitis by both light and electron microscopy using the indirect peroxidase-labeled antibody method. In all patients with PBC, Fas was observed on the surface of epithelial cells of interlobular bile ducts.<br>By electron microscopy, electron-dense reaction products of Fas were detected on the basolateral plasma membrane of the bile duct epithelial cells, as well as on some membranes of the endoplasmic reticulum. Fas was expressed more strongly on the surface of the epithelial cells of interlobular bile ducts in PBC than of those in chronic hepatitis. These findings suggest that increased expression of Fas on such bile ducts may play some role in the pathogenesis of PBC.

収録刊行物

• 岡山医学会雑誌

  岡山医学会雑誌 114 (3), 283-288, 2003

  岡山医学会

キーワード

• Fas
• apoptosis
• liver
• primary biliary cirrhosis
• immunoelectron microscopy

詳細情報

• CRID: 1390282679853134976
• NII論文ID: 130006857956
• NII論文ID: 10012337202
• NII書誌ID: AN00032489
• DOI: 10.4044/joma1947.114.3_283
• ISSN: 18824528
• ISSN: 00301558
• Web Site: https://ousar.lib.okayama-u.ac.jp/13575
• Web Site: https://www.jstage.jst.go.jp/article/joma1947/114/3/114_3_283/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003248177
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