キシラジン・リドカイン混合液による牛の腰椎分節硬膜外麻酔時のエフェドリン投与効果

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  • Pressor Effects of Ephedrine in Cows with Segmental Lumbar Epidural Analgesia Induced by a Combination of Xylazine/Lidocaine.

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Segmental lumbar epidural analgesia (SLEA) was performed in 17 Holstein cows (three cows were used twice at weekly intervals) by administration of a combination of xylazine/lidocaine (XL) through indwelling epidural catheters. The cows were divided into 5 groups, a control group and 4 treatment groups (n=4; 3 cows were used twice) . The cows of each group were given ephedrine hydrochloride 10 min before XL epidural injection at 0.2 mg/kg intravenously, 0.2 mg/kg epidurally, 0.5 mg/kg subcutaneously and 1.0 mg/kg subcutaneously, respectively. Control group, with no ephedrine treatment, showed about 20% decrease in mean arterial blood pressuae (MABP) at 30, 60, 90 and 120 min after XL epidural injection. MABP decreased about 10 and 15% in groups with epidural and intravenous ephedrine administration, respectively, and increased more than 20% with shorter duration of sedative effect in the group where 1.0 mg/kg ephedrine was administered subcutaneously. The group administered 0.5 mg/kg ephedrine subcutaneously maintained MABP at baseline level without affecting the analgesic and sedative effects of SLEA induced by XL.

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