Use of probiotics in inflammatory bowel disease

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  • Sasaki M.
    Department of Internal Medicine, Division of Gastroenterology, Shiga University of Medical Science
  • Andoh A.
    Department of Internal Medicine, Division of Gastroenterology, Shiga University of Medical Science
  • Tsujikawa T.
    Department of Internal Medicine, Division of Gastroenterology, Shiga University of Medical Science
  • Fujiyama Y.
    Department of Internal Medicine, Division of Gastroenterology, Shiga University of Medical Science

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  • ＩＢＤに対する最新の内科治療　　治療成績と効果発現機序に関するｒｅｖｉｅｗ　　３．炎症性腸疾患に対するｐｒｏｂｉｏｔｉｃｓの効果

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Abstract

Intestinal microflora plays an important role in the pathogenesis in inflammatory bowel disease (IBD). Probiotics are microbial organisms which improve microfloral balance and have a beneficial effect on health. Recent attention has focused on the potential of probiotics to treat and prevent IBD. Evidence from human studies and experimental animal models suggest a significant relationship between the enteric microflora and intestinal inflammation. The field of probiotics is complex, and the mechanisms of its action have not yet been elucidated. However, controlled clinical trials have shown that probiotics are useful tools in the treatment or maintenance of remission in Crohn's disease, ulcerative colitis or pouchitis. The probiotic mixture VSL # 3 in particular has been demonstrated to be efficacious in the prevention of pouchitis. Randomized control trials are necessary to establish the efficacy of probiotics in the Japanese IBD population.

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