Cardiac Hypertrophy by Hypertension and Exercise Training Exhibits Different Gene Expression of Enzymes in Energy Metabolism

DOI PubMed 3 Citations 77 References
  • IEMITSU Motoyuki
    Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine
  • MIYAUCHI Takashi
    Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine Center for Tsukuba Advanced Research Alliance, University of Tsukuba
  • MAEDA Seiji
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba Institute of Health and Sport Sciences, University of Tsukuba
  • SAKAI Satoshi
    Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine
  • FUJII Nobuharu
    Gene Experiment Center, Institute of Applied Biochemistry, University of Tsukuba
  • MIYAZAKI Hitoshi
    Gene Experiment Center, Institute of Applied Biochemistry, University of Tsukuba
  • KAKINUMA Yoshihiko
    Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine
  • MATSUDA Mitsuo
    Institute of Health and Sport Sciences, University of Tsukuba
  • YAMAGUCHI Iwao
    Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine

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Abstract

Hypertension-induced pathological cardiac hypertrophy (hypertensive heart) and exercise training-induced physiological cardiac hypertrophy (athletic heart) have differences in cardiac properties. We hypothesized that gene expression of energy metabolic enzymes differs between these two types of cardiac hypertrophy. To investigate whether mRNA expression of key enzymes in the long-chain fatty acid (FA), glucose, and lactic acid metabolic pathways differs between these two types of cardiac hypertrophy, we used the hearts of spontaneously hypertensive rats (SHR; 19 weeks old) as a model of the hypertensive heart, swim-trained rats (Trained; 19 weeks old, swimming training for 15 weeks) as a model of the athletic heart, and sedentary Wistar-Kyoto rats (Control; 19 weeks old). SHR developed hypertensive cardiac hypertrophy, of which cardiac function was deteriorated, whereas Trained rats developed an athletic heart, of which cardiac function was enhanced. The mRNA expression of CD36, which involved in uptake of long-chain FA, in the heart was almost never detected in the SHR group. Furthermore, the mRNA expression of key enzymes in the long-chain FA metabolic pathway (acyl CoA synthase [ACoAS], carnitine palmitoyl transferase [CPT]-I, CPT-II, and isocitrate dehydrogenase [ISCD]) in the heart was significantly higher in the SHR group compared with the Control group. The mRNA expression of ACoAS, CPT-I, ISCD, and CD36 in the heart did not differ between Trained group and Control group, whereas that of CPT-II in the Trained group was significantly higher compared with the Control group. The mRNA expression of key enzymes (phosphofructokinase and lactate dehydrogenase) in glycolytic metabolic pathway in the heart was markedly higher in the SHR group compared with the Control group, whereas these mRNA expressions did not differ between Trained group and Control group. These findings suggest that the molecular phenotypes in the energy metabolic system differ in hypertension-induced pathological and exercise training-induced physiological cardiac hypertrophy, and these differences may participate in the differences in cardiac function. (Hypertens Res 2003; 26: 829-837)

Journal

  • Hypertension Research

    Hypertension Research 26 (10), 829-837, 2003

    The Japanese Society of Hypertension

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