Angiotensin II-Induced Ventricular Hypertrophy and Extracellular Signal-Regulated Kinase Activation Are Suppressed in Mice Overexpressing Brain Natriuretic Peptide in Circulation

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著者

    • TAKAHASHI Nobuki
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • SAITO Yoshihiko
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • KUWAHARA Koichiro
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • HARADA Masaki
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • KISHIMOTO Ichiro
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • OGAWA Yoshihiro
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • KAWAKAMI Rika
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • NAKAGAWA Yasuaki
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • NAKANISHI Michio
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • NAKAO Kazuwa
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine

抄録

<B>Atrial and brain (B-type) natriuretic peptides (ANP and BNP, respectively) are known to exert various cardioprotective effects. For instance, knocking out the expression of ANP, BNP, or their receptor, guanylyl cyclase-A, induces cardiac hypertrophy and/or fibrosis. The cardiac effects of elevated circulating natriuretic peptides are less well understood, however. We therefore compared angiotensin (Ang) II-induced cardiac hypertrophy and fibrosis in BNP-transgenic (Tg) mice, in which circulating BNP levels were elevated by increased secretion from the liver, and their non-Tg littermates. Left ventricular expression of Ang II type 1a receptor was similar in BNP-Tg and non-Tg mice, and there was no significant difference in the elevation of blood pressure elicited by chronic infusion or acute injection of Ang II. Nevertheless, cardiac hypertrophy and fibrosis were significantly diminished in BNP-Tg mice chronically infused with Ang II. In addition, ventricular activation of extracellular signal-regulated kinase (ERK) induced by acute injection of Ang II was also diminished in BNP-Tg mice, as was activation of ERK kinase (MEK). Conversely, expression of mitogen-activated protein kinase phosphatase (MKP) was significantly increased in the ventricles of BNP-Tg mice. Based on these findings, we conclude that elevated circulating BNP exerts cardioprotective effects <I>via</I> inhibition of a ventricular ERK pathway. The mechanism responsible for this inhibition likely involves 1) increased ventricular MKP expression and 2) inhibition of transduction mediators situated upstream of ERK. (<I>Hypertens Res</I> 2003; 26: 847-853)</B>

収録刊行物

  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 26(10), 847-853, 2003-10-01

    The Japanese Society of Hypertension

参考文献:  37件中 1-37件 を表示

被引用文献:  2件中 1-2件 を表示

  • Hypertensive Heart Disease

    DIAMOND Joseph A. , PHILLIPS Robert A.

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 28(3), 191-202, 2005-03-01

    医中誌Web 参考文献101件 被引用文献13件

  • Long-Term Vardenafil Therapy Improves Hemodynamics in Patients with Pulmonary Hypertension

    AIZAWA Kazunori , HANAOKA Takeshi , KASAI Hiroki , KOGASHI Kaoru , KUMAZAKI Setsuo , KOYAMA Jun , TSUTSUI Hiroshi , YAZAKI Yoshikazu , WATANABE Noboru , KINOSHITA Osamu , IKEDA Uichi

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 29(2), 123-128, 2006-02-01

    医中誌Web 参考文献31件 被引用文献1件

各種コード

  • NII論文ID(NAID)
    10012457798
  • NII書誌ID(NCID)
    AA10847079
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09169636
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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