Role of the Nh (Non-hair) Mutation in the Development of Dermatitis and Hyperproduction of IgE in DS-Nh Mice

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The DS-<i>Nh</i> (DS Non-hair) mouse is a spontaneous hairless mutant of the DS mouse. The inheritance mode of the <i>Nh</i> mutation is autosomal dominant, and the <i>Nh</i> locus is mapped to Chromosome 11. The roles of the <i>Nh</i> mutation in spontaneous dermatitis and IgE hyperproduction were studied using an <i>Nh</i> congenic strain with a genetic background from the BALB/c mouse. In contrast to DS-<i>Nh</i> (<i>Nh</i>/+) mice, BALB/c-<i>Nh</i> (<i>Nh</i>/+) mice under conventional conditions showed a marked increase in serum IgE, without the development of dermatitis. These results suggest that IgE hyperproduction is regulated by the <i>Nh</i> mutation, while other genetic factor(s) are also involved in the development of dermatitis.<br>

収録刊行物

  • Experimental animals

    Experimental animals 52(5), 419-423, 2003-10-01

    Japanese Association for Laboratory Animal Science

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各種コード

  • NII論文ID(NAID)
    10012458053
  • NII書誌ID(NCID)
    AA11032321
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    13411357
  • NDL 記事登録ID
    6707279
  • NDL 雑誌分類
    ZS7(科学技術--医学)
  • NDL 請求記号
    Z54-H752
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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