Pain-related Differential Expression of NGF, GDNF, IL-6, and Their Receptors in Human Vasculitic Neuropathies

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<i>Objective</i> Pain-related differential expressions of nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF) and interleukin-6 (IL-6), and their receptors were investigated in human vasculitic neuropathies.<br> <i>Materials and Methods</i> The mRNA levels of painrelated neurotrophic factors, NGF, GDNF and IL-6, were examined in the sural nerves of 22 painful and non-painful patients with acute necrotizing vasculitic neuropathies, together with their concomitant soluble receptors (p75, GFRα-1 and IL-6Rα).<br> <i>Results</i> The mRNAs for these factors and receptors in the lesioned nerves were up-regulated to a variable extent in both groups. NGF mRNA expression was more closely correlated with that of p75 in painful neuropathy with relatively preserved large fiber density, compared with non-painful neuropathy, though the NGF mRNA level in painful neuropathy was lower than that in non-painful neuropathy. GDNF was closely associated with GFRα-1 in mRNA levels regardless of the pain state, but IL-6 was not associated with IL-6Rα.<br> <i>Conclusion</i> The differential expression of neurotrophic factors and their cognate soluble receptors in human vasculitic neuropathy suggests that NGF, which was effectively transferred to sensory axons with p75, may induce pain.<br>(Internal Medicine 42: 1100-1103, 2003)

収録刊行物

  • Internal medicine

    Internal medicine 42(11), 1100-1103, 2003-11-01

    The Japanese Society of Internal Medicine

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各種コード

  • NII論文ID(NAID)
    10012544332
  • NII書誌ID(NCID)
    AA10827774
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09182918
  • NDL 記事登録ID
    6769800
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z53-M398
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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