Dietary Vitamin B6 Suppresses Colon Tumorigenesis, 8-Hydroxyguanosine, 4-Hydroxynonenal, and Inducible Nitric Oxide Synthase Protein in Azoxymethane-Treated Mice.
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- KOMATSU Shun-ichiro
- Faculty of Applied Biological Science, Hiroshima University
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- WATANABE Hiromitsu
- Research Institute for Radiation Biology and Medicine, Hiroshima University
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- OKA Tatsuzo
- Faculty of Agriculture, Kagoshima University
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- TSUGE Haruhito
- Faculty of Agriculture, Gifu University
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- KATO Norihisa
- Faculty of Applied Biological Science, Hiroshima University
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抄録
Recently we reported that the supplementation of vitamin B6 to low vitamin B6 diet caused suppression in colon tumorigenesis and cell proliferation of azoxymethanetreated mice in a dose-dependent manner among 1, 7, and 14mg pyridoxine HCl/kg diet (J Nutr 131: 2204-2207, 2001). To examine the mechanism of the anticolon tumor effect of vitamin B6, male ICR mice were fed the diet containing 1, 7, 14, and 35 mg pyridoxine HCl/kg diet for 22 wk and simultaneously given a weekly injection of azoxymethane for an initial 10 wk. The supplementation of vitamin B6 to a low vitamin B6 diet (1 mg pyridoxine HCl/kg) suppressed the levels of colonic 8-hydroxyguanosine and 4-hydroxynonenal and in-ducible nitric oxide synthase protein. The results suggest that the preventive effect of vita-min B6 against colon tumorigenesis is at least in part mediated by reducing oxidative stress and nitric oxide production.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 48 (1), 65-68, 2002
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詳細情報 詳細情報について
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- CRID
- 1390001206325406464
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- NII論文ID
- 10012603390
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD38Xis1WntbY%3D
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- ISSN
- 18817742
- 03014800
- http://id.crossref.org/issn/03014800
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- NDL書誌ID
- 6262323
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- PubMed
- 12026192
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可