Cyanidin 3-O-β-D-Glucoside Attenuates the Hepatic Ischemia-Reperfusion Injury through a Decrease in the Neutrophil Chemoattractant Production in Rats
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- TSUDA Takanori
- Junior College Division, Tokai Gakuen University
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- HORIO Fumihiko
- Nagoya University Graduate School of Eioagricultural Sciences
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- KATO Yoji
- School of Humanities for Environmental Policy and Technology, Himeji Institute of Technology
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- OSAWA Toshihiko
- Nagoya University Graduate School of Eioagricultural Sciences
書誌事項
- タイトル別名
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- Cyanidin 3-O-.BETA.-D-Glucoside Attenuates the Hepatic Ischemia-Reperfusion Injury through a Decrease in the Neutrophil Chemoattractant Production in Rats.
- Cyanidin 3 O ベータ D Glucoside Attenuates the Hepatic Ischemia Reperfusion Injury through a Decrease in the Neutrophil Chemoattractant Production in Rats
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We have shown that the orally administered cyanidin 3-O-β-D-glucoside (C3G) attenuates the hepatic ischemia-reperfusion (I/R) injury, which was used as a model for oxidative stress through a decrease in neutrophil chemoattractant production in rats. The rats were subjected to hepatic I/R at 30 min after the administration of C3G (0.9 mmol/kg body weight) or vehicle. I/R treatment resulted in the elevation of oxidative stress marker [liver thiobarbituric acid-reactive substance, Nε-(hexanonyl) lysine and dity-rosine] levels in the liver and of the serum activities of marker enzymes for liver injury. The administration of C3G significantly suppressed these elevations, which had been caused by hepatic I/R. Liver myeloperoxidase activity, a useful marker for neutrophil infiltration into tissues, and the plasma and liver concentration of cytokine-induced neutrophil chemoattractant-1(CINC-1), which has a potent chemotactic activity, were markedly elevated in the control group after hepatic I/R. However, these elevations were significantly suppressed in the C3G group. C3G and its metabolites in the plasma and liver were detected in the C3G group after hepatic I/R. These results suggest that the absorbed C3G and/or its metabolites can act as antioxidants in the blood and liver and scavenge the reactive oxygen species, and brought on a decrease in neutrophil infiltration into the liver through the suppression of CINC-1 production and the tissue damage caused by neutrophils after I/R is attenuated.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 48 (2), 134-141, 2002
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詳細情報 詳細情報について
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- CRID
- 1390282681302228352
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- NII論文ID
- 10012603803
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD38XktlGjtL0%3D
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- ISSN
- 18817742
- 03014800
- http://id.crossref.org/issn/03014800
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- NDL書誌ID
- 6267515
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- PubMed
- 12171434
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可