二次的血管柄付骨移植片による顎骨再建に関する実験的研究 Experimental study of jaw bone reconstruction with prefabricated vascularized bone grafts

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著者

    • 堀内 薫 HORIUCHI Kaoru
    • 大阪歯科大学口腔外科学第1講座 First Department of Oral and Maxillofacial Surgery, Osaka Dental University
    • 久保 誼修 KUBO Yoshinobu
    • 大阪歯科大学口腔外科学第1講座 First Department of Oral and Maxillofacial Surgery, Osaka Dental University
    • 福田 あおい FUKUDA Aoi
    • 大阪歯科大学口腔外科学第1講座 First Department of Oral and Maxillofacial Surgery, Osaka Dental University
    • 虫本 浩三 MUSHIMOTO Kozo
    • 大阪歯科大学口腔外科学第1講座 First Department of Oral and Maxillofacial Surgery, Osaka Dental University

抄録

Bone grafting has been clinically used to repair jaw bone defects. Autologous bone grafting is frequently performed and has produced good clinical results as compared with other types of bone grafting. However, the use of this procedure is limited by anatomical reasons such as the site and amount of collected autologous bone. We have experimentally established methods for producing secondary vascularized bone grafts with minimal sacrifice of autologous bone, but with ossification of reliable size and structure. To investigate the possibility of clinically using the produced ectopic bone, a long-term quantitative evaluation was performed with the use of peripheral quantitative computed tomography (pQCT). As control, autologous vessel bundles were produced by abrading the femoral artery and vein of 8 -week-old male Wistar rats and were wrapped in an artificial vessel (e-PTFE membrane). In one experimental group, autologous cancellous bone chips were added to the same treatment as in the control group. In the other experimental group, autologous cortical bone chips were added to the same treatment as in the control group. The animals were killed 6, 9, 12, 18, and 24 weeks after the surgical procedure, and the status of osteogenesis was observed by means of soft X-ray film, histological examination and quantitative evaluation using pQCT. Serial long-term increases in bone density of the produced ectopic bones were present for 24 weeks after the surgical procedure (both experimental groups), with no marked differences from the normal femur. Our results suggest that the produced ectopic bone can be used clinically as a new source of vascularized bone grafts.

収録刊行物

  • 日本口腔外科学会雑誌

    日本口腔外科学会雑誌 49(7), 423-430, 2003-07-20

    Japanese Society of Oral and Maxillofacial Surgeons

参考文献:  35件中 1-35件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10012629561
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00215163
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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