二次的血管柄付骨移植片による顎骨再建に関する実験的研究

DOI 被引用文献1件 参考文献35件

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  • Experimental study of jaw bone reconstruction with prefabricated vascularized bone grafts

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Bone grafting has been clinically used to repair jaw bone defects. Autologous bone grafting is frequently performed and has produced good clinical results as compared with other types of bone grafting. However, the use of this procedure is limited by anatomical reasons such as the site and amount of collected autologous bone. We have experimentally established methods for producing secondary vascularized bone grafts with minimal sacrifice of autologous bone, but with ossification of reliable size and structure. To investigate the possibility of clinically using the produced ectopic bone, a long-term quantitative evaluation was performed with the use of peripheral quantitative computed tomography (pQCT). As control, autologous vessel bundles were produced by abrading the femoral artery and vein of 8 -week-old male Wistar rats and were wrapped in an artificial vessel (e-PTFE membrane). In one experimental group, autologous cancellous bone chips were added to the same treatment as in the control group. In the other experimental group, autologous cortical bone chips were added to the same treatment as in the control group. The animals were killed 6, 9, 12, 18, and 24 weeks after the surgical procedure, and the status of osteogenesis was observed by means of soft X-ray film, histological examination and quantitative evaluation using pQCT. Serial long-term increases in bone density of the produced ectopic bones were present for 24 weeks after the surgical procedure (both experimental groups), with no marked differences from the normal femur. Our results suggest that the produced ectopic bone can be used clinically as a new source of vascularized bone grafts.

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