QOLとしての咀嚼器官: ストレスとの関連性

DOI 被引用文献4件 参考文献40件

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  • The role of Masticatory Organs as QOL: The Interactions between the Masticatory Organ and Stress

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Because we are usually exposed to the stress by the rapid change of the environment surrounding our circumference, studies on the mechanism (s) underlying stress is required for maintaining our health. Based on recent findings regarding the involvement of the oral organ in the stress, we have reviewed the literature to evaluate the possible interactions between this organ and stress. The occlusal stress, resulted from dysfunction of the masticatory organ, induces various systemic diseases, such as headache, shoulder discomfort, or abnormal attitude. Interestingly, in the aged animal, abnormal occlusion, which is prepared by cut off of the crown portion of the upper molar teeth, extraction of the upper molar teeth, or cut of the one side of the masseteric nerve, elevates plasma corticosterone levels, and facilitates the age-related hippocampal cell death and impairment of spatial cognition. These abnormalities are inhibited by application of metyrapone, a corticosterone antagonist, suggesting the involvement of occlusal stress in the senile processes of memory storage. On the other hand, in rats under stressful conditions, biting can reduce stress-elevated plasma corticosterone levels and stress-induced increase in neuronal activity in the limbic system. In human subjects, also, either chewing or clenching is able to inhibit the stressful noise-induced increase in neuronal activities in the amygdala and stressful noise-induced elevation in the plasma levels of catecholamines (adrenaline, noradrenaline and dopamine) and ACTH. These results are very important in understanding the mechanism underlying that humans often chew gum to help with stress relief.

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