糖尿病におけるリポ蛋白中のコレステロール分画・トリグリセライド分画比と変性LDLの相関性

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タイトル別名
  • Lipoprotein fractionation by agarose gel electrophoresis and differential staining of lipids in patients with diabetes mellitus.
  • トウニョウビョウ ニ オケル リポ タンパク チュウ ノ コレステロール ブンカク トリグリセライド ブンカクヒ ト ヘンセイ LDL ノ ソウカンセイ

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Abnormalities of serum lipid and lipoprotein concentrations are common in type II (non-insulin-dependent) diabetes mellitus. This study was to determine lipids and lipoprotein composition, and relationship between lipoprotein abnormalities and complications in diabetic patients. Lipoprotein profile was analyzed by simultaneous determination of serum cholesterol and triglyceride fractions. Modified LDL was quantified as relative change of the mobility shift of LDL fraction (charge modification frequency; CMF). 184 diabetic patients and 64 control subjects were analyzed by this method. No difference in fasting plasma glucose and hemoglobin A1c was observed between modified LDL positive and negative diabetic patients. In contrast, significant difference in conventional lipids, HDL/LDL fractions, appearance of IDL and distribution of lipoprotein phenotype by WHO classification were observed. In diabetic patients, increasing CMF had negative correlation with frequency of type IIa and positive correlation with type IIb and IV. Furthermore, increasing CMF was associated with a progression of nephropathy. Independent association was observed for retinopathy. We suggest that the serum lipoprotein pattern may provide an additional tool for monitoring the progression of hyperlipidemia and nephropathy in diabetes mellitus.

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