Cytokine expressions and H. pylori-associated gastric mucosal lesion

• Takagi Atsushi

  General Internal Medicine, Tokai University School of Medicine

• Deguchi Ryuzo

  Gastroenterology, Tokai University School of Medicine

• Kobayashi Kenji

  Gastroenterology, Tokai University School of Medicine

• Miwa Takeshi

  Gastroenterology, Tokai University School of Medicine

書誌事項

タイトル別名

• Cytokine expressions and <i>H. pylori</i>-associated gastric mucosal lesion

抄録

To determine the role of host genetic factors in Helicobacter pylori infection, we examined the relation between gastroduodenal diseases and IL-1B polymorphisms in patients with H. pylori infection. In addition, we also compared gastric mucosal cytokine levels in those patients. We confirmed the findings that the IL-1B-31 C-to-T base transition was inverted in association with the -511 T-to-C base transition. There was no relation regarding to IL-1B polymorphisms and clinical outcomes. The gastric mucosal IL-1B level of the body of the stomach but not the antrum was significantly different among IL-1B genotypes. Furthermore, the IL-8 levels in the body were also higher in IL-1B-511C/C/ IL-1B-31TT than H. pylori negative patients. These findings suggested that IL-1B polymorphisms enhance not only IL-1-B production but also IL-8 production in the gastric body and may play an important role in the development of atrophic gastritis.

収録刊行物

• Ｔｈｅ　Ｋｅｉｏ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎｅ

  Ｔｈｅ　Ｋｅｉｏ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎｅ 51 (supplement2), 51-52, 2002

  The Keio Journal of Medicine

キーワード

• <i>H. pylori</i> infection
• interleukin-1 gene polymorphisms
• interleukin-1
• interleukin-8

詳細情報

• CRID: 1390001206336778368
• NII論文ID: 10012735024
• NII書誌ID: AA00710216
• DOI: 10.2302/kjm.51.supplement2_51
• ISSN: 18801293
• ISSN: 00229717
• Web Site: https://www.jstage.jst.go.jp/article/kjm1952/51/supplement2/51_supplement2_51/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003220404
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可