Infrequent APC Mutations in Serrated Adenoma.

• Dehari Reiko

  Department of Internal Medicine, Tokyo University School of Medicine Department of Pathology, Yamagata University School of Medicine

Abstract

In 1990, Longacre and Fenoglio-Preiser introduced “serrated adenoma (SA)” combining architectural and cytological features of hyperplastic polyp and adenomatous epithelium. It has been reported that intramucosal carcinoma occurs in 10% of SAs. Although there have been many reports on SAs, its histogenesis and natural history still remain unknown. To clarify the genetic changes in SA, APC mutations in 28 SAs, 4 adenocarcinomas in/with SAs, 12 tubular adenomas (TAs) and 10 adenocarcinomas in/with TAs were evaluated in the present study. After polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) analyses, gene mutations were confirmed by direct sequencing. No APC mutation was detected in adenocarcinomas in/with SAs, and only one SA without adenocarcinoma (3.8%) was found to be positive for APC gene mutation, whereas the mutations were found in 66.7% of TAs and in 50% of adenocarcinomas in/with TAs. The frequency of APC gene mutation in SAs was significantly lower than that in control sporadic TAs. These findings suggest that SAs are genetically different from TAs.

Journal

• The Tohoku Journal of Experimental Medicine

  The Tohoku Journal of Experimental Medicine 193 (3), 181-186, 2001

  Tohoku University Medical Press

Keywords

• colorectum
• serrated adenoma
• APC
• mutation
• PCR-SSCP

Details

• CRID: 1390001204241556608
• NII Article ID: 10012759551
• NII Book ID: AA00863920
• DOI: 10.1620/tjem.193.181
• COI: 1:CAS:528:DC%2BD3MXjslemu7g%3D
• ISSN: 13493329
• ISSN: 00408727
• PubMed: 11315765
• Web Site: http://www.jstage.jst.go.jp/article/tjem/193/3/193_3_181/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001234652
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed