Dysfunction of Dendritic and T Cells as the Cause of Immune Suppression in HTLV-I Infected Individuals

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Human T lymphotropic virus type I (HTLV-I) impairs cellular immunity and can develop into adult T cell leukemia/lymphoma (ATLL). The Role of dendritic cells (DC) has not been fully elucidated in individuals infected by HTLV-I. To address this issue, we studied several cellular parameters, including phenotypic and functional characteristics of monocyte-derived DC. Generated DC exhibited down-regulation in the expression of CD1a and HLA-DR in HTLV-I carriers, suggesting partial impairment of maturation. T cells were stimulated by autologous DC in half of HTLV-I carriers, as well as healthy donors, but not in ATLL patients. Because of the importance of CD40-CD40 ligand (CD40L) signaling in establishing an inflammatory immune response, we also investigated the expression of soluble CD40L (sCD40L) of PHA-activated lymphocytes from HTLV-I infected individuals. sCD40L was detected in the culture supernatant of lymphocytes from one of four HTLV-I carriers investigated. These results suggest that the defect or aberration in the function of DC and the expression of sCD40L in T cells is associated with immune suppression in HTLV-I infected individuals.

収録刊行物

  • Journal of clinical and experimental hematopathology

    Journal of clinical and experimental hematopathology 43(2), 43-48, 2003-10-01

    The Japanese Society for Lymphoreticular Tissue Research

参考文献:  28件中 1-28件 を表示

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各種コード

  • NII論文ID(NAID)
    10012809403
  • NII書誌ID(NCID)
    AA11556796
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13464280
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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