Enantiomerically Convergent Synthesis of Phosphatidyl-<scp>d</scp>-<i>myo</i>-inositol 3,5-Bisphosphate from Both <scp>l</scp>- and <scp>d</scp>-1,2-<i>O</i>-Cyclohexylidene-<i>myo</i>-inositol

• Fushe Han

  Venture Business Laboratory, Ehime UniversityMatsuyama

• Minoru Hayashi

  Department of Applied Chemistry, Faculty of Engineering, Ehime UniversityMatsuyama

• Yutaka Watanabe

  Department of Applied Chemistry, Faculty of Engineering, Ehime UniversityMatsuyama

抄録

The synthesis of phosphatidyl-d-myo-inositol 3,5-bisphosphate [PtdIns(3,5)P2] has been conveniently accomplished via convergent routes starting from both enantiomers, 1,2-O-cyclohexylidene-myo-inositol. The synthetic strategy involves completely regioselective phosphorylation of 3,4-diol and 2,3,6-triol of the suitably protected inositols with the corresponding phosphite in the presence of pyridinium tribromide and 2,6-lutidine, resulting in the formation of 3-O-phosphorylated products, respectively.

収録刊行物

• Chemistry Letters

  Chemistry Letters 32 (8), 724-725, 2003-07-14

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360002219110317440
• NII論文ID: 10012818362
• NII書誌ID: AA00603318
• DOI: 10.1246/cl.2003.724
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/32/8/724/55581454/cl.2003.724.pdf
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