Enantiomerically Convergent Synthesis of Phosphatidyl-D-myo-inositol 3, 5-Bisphosphate from Both L- and D-1, 2-O-Cyclohexylidene-myo-inositol

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著者

    • HAN Fushe
    • Venture Business Laboratory, Ehime University
    • HAYASHI Minoru
    • Department of Applied Chemistry, Faculty of Engineering, Ehime University
    • WATANABE Yutaka
    • Department of Applied Chemistry, Faculty of Engineering, Ehime University

抄録

The synthesis of phosphatidyl-<FONT SIZE="-2">D</FONT>-<I>myo</I>-inositol 3,5-bisphosphate [PtdIns(3,5)P2] has been conveniently accomplished via convergent routes starting from both enantiomers, 1,2-<I>O</I>-cyclohexylidene-<I>myo</I>-inositol. The synthetic strategy involves completely regioselective phosphorylation of 3,4-diol and 2,3,6-triol of the suitably protected inositols with the corresponding phosphite in the presence of pyridinium tribromide and 2,6-lutidine, resulting in the formation of 3-<I>O</I>-phosphorylated products, respectively.

収録刊行物

  • Chemistry letters

    Chemistry letters 32(8), 724-725, 2003-08-05

    The Chemical Society of Japan

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各種コード

  • NII論文ID(NAID)
    10012818362
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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