Remission induction of refractory diffuse large B-cell lymphoma with allogeneic peripheral blood stem cell transplantation followed by interferon-α and donor lymphocyte infusion

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  • KAWANO Ichiro
    First Department of Internal Medicine, University of Occupational and Environmental Health
  • TSUKADA Junichi
    First Department of Internal Medicine, University of Occupational and Environmental Health
  • TODA Yoko
    First Department of Internal Medicine, University of Occupational and Environmental Health
  • OGAWA Ryosuke
    First Department of Internal Medicine, University of Occupational and Environmental Health
  • HIGASHI Takehiro
    First Department of Internal Medicine, University of Occupational and Environmental Health
  • IWASHIGE Atsushi
    First Department of Internal Medicine, University of Occupational and Environmental Health
  • OTA Takanori
    First Department of Internal Medicine, University of Occupational and Environmental Health
  • KUBOTA Ayumu
    First Department of Internal Medicine, University of Occupational and Environmental Health
  • MIZOBE Takamitsu
    First Department of Internal Medicine, University of Occupational and Environmental Health
  • MORIMOTO Hiroaki
    First Department of Internal Medicine, University of Occupational and Environmental Health
  • MACHIDA Shinichiro
    First Department of Internal Medicine, University of Occupational and Environmental Health
  • TANAKA Yoshiya
    First Department of Internal Medicine, University of Occupational and Environmental Health

Bibliographic Information

Other Title
  • 同種末梢血幹細胞移植後，インターフェロンα併用ドナーリンパ球輸注にて寛解となった治療抵抗性び慢性大細胞型B細胞リンパ腫
  • 症例 同種末梢血幹細胞移植後,インターフェロンα併用ドナーリンパ球輸注にて寛解となった治療抵抗性び慢性大細胞型B細胞リンパ腫
  • ショウレイ ドウシュ マッショウケツ カンサイボウ イショク ゴ インターフェロン アルファ ヘイヨウ ドナーリンパキュウ ユチュウ ニテ カンカイ ト ナッタ チリョウ テイコウセイ ビ マンセイ ダイ サイボウガタ B サイボウ リンパ シュ

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Abstract

Graft-versus-lymphoma (GVL) effect has been described in patients with malignant lymphoma after allogeneic stem cell transplantation (alloSCT). The effect of interferon-α (IFN-α) on the GVL effect still remains unclear. Here we report on a 29-year-old woman with refractory diffuse large B-cell lymphoma (DLBL). Her clinical findings included multiple masses in the liver, stomach, bilateral kidneys, thyroid, vertebral bones and a bulky mediastinal mass. Since the patient did not respond to various combination chemotherapies and further developed superior vena cava syndrome, allogeneic peripheral blood stem cell transplantation (PBSCT) from a HLA-identical brother was carried out after a myeloablative TBI/CY-based conditioning regimen. DLIs have been also performed every 4 weeks since day +14. As a result, the lymphoma masses showed a partial response. In order to enhance the GVL effect, IFN-α was further given at a maximum of 3 MU four times per week. Although the patient only experienced graft-versus-host disease of the skin (grade II) even after both DLIs and IFN, complete clinical remission was observed. 200 days after transplantation, the patient is still disease-free and in good condition. This report suggests the curative potential of IFN-α combined with DLI after allogeneic SCT in refractory DLBL.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 45 (2), 155-160, 2004

    The Japanese Society of Hematology

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