分子生物学的に同一クローンの再発を確認しえた biphenotypic leukemia Relapse of biphenotypic leukemia confirmed by molecular study
A 60-year-old woman was admitted to our hospital to receive treatment for relapse of biphenotypic leukemia 4 years after initial presentation. Bone marrow examination revealed 53.5% lymphoblasts, which were classified as ALL-L2 with normal karyotype. Surface markers of lymphoblasts were positive for both B-cell and myeloid lineage. Immunoglobulin heavy chain and T-cell receptor gene rearrangements were investigated by PCR. Clonal rearrangement of TCRδ Vδ2-Dδ3 was detected. The same clonal rearrangement of TCRδ was found using frozen initial leukemic cells. Her leukemia was confirmed as not secondary leukemia but relapse of the initial clone. Detection of the rearrangement was also useful as a patient-specific marker for minimal residual disease.
- 臨床血液 = The Japanese Journal of Clinical Hematology
臨床血液 = The Japanese Journal of Clinical Hematology 45(2), 161-163, 2004-02-29