分子生物学的に同一クローンの再発を確認しえた biphenotypic leukemia Relapse of biphenotypic leukemia confirmed by molecular study

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著者

    • 橋野 聡 HASHINO Satoshi
    • 北海道大学医学部第三内科 Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine
    • 泉山 康 [他] IZUMIYAMA Koh
    • 北海道大学医学部第三内科 Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine
    • 千葉 広司 CHIBA Kouji
    • 北海道大学医学部第三内科 Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine
    • 近藤 健 KONDO Takeshi
    • 北海道大学医学部第三内科 Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine
    • 田中 淳司 TANAKA Junji
    • 北海道大学医学部血液内科 Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine
    • 浅香 正博 ASAKA Masahiro
    • 北海道大学医学部第三内科 Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine

抄録

A 60-year-old woman was admitted to our hospital to receive treatment for relapse of biphenotypic leukemia 4 years after initial presentation. Bone marrow examination revealed 53.5% lymphoblasts, which were classified as ALL-L2 with normal karyotype. Surface markers of lymphoblasts were positive for both B-cell and myeloid lineage. Immunoglobulin heavy chain and T-cell receptor gene rearrangements were investigated by PCR. Clonal rearrangement of TCRδ Vδ2-Dδ3 was detected. The same clonal rearrangement of TCRδ was found using frozen initial leukemic cells. Her leukemia was confirmed as not secondary leukemia but relapse of the initial clone. Detection of the rearrangement was also useful as a patient-specific marker for minimal residual disease.

収録刊行物

  • 臨床血液 = The Japanese Journal of Clinical Hematology

    臨床血液 = The Japanese Journal of Clinical Hematology 45(2), 161-163, 2004-02-29

    日本臨床血液学会

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各種コード

  • NII論文ID(NAID)
    10012841909
  • NII書誌ID(NCID)
    AN00252940
  • 本文言語コード
    JPN
  • 資料種別
    SHO
  • ISSN
    04851439
  • NDL 記事登録ID
    6874855
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z19-295
  • データ提供元
    CJP書誌  NDL  IR 
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