Combined Treatment with an AT_1 Receptor Blocker and Angiotensin Converting Enzyme Inhibitor Has an Additive Effect on Inhibiting Neointima Formation via Improvement of Nitric Oxide Production and Suppression of Oxidative Stress

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<B>Accumulating evidence shows that inhibition of the vascular renin-angiotensin system results in suppression of injury-elicited neointima formation. We attempted to determine whether or not combined treatment with an angiotensin II type 1 receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI) has an additive inhibitory effect on balloon-injury-elicited neointima formation in the carotid artery. Male Sprague-Dawley rats were treated with an ARB (valsartan: 3 mg/kg/day) and/or an ACEI (benazepril: 0.3 mg/kg/day) from 1 week before until 2 weeks after balloon injury. Experiments were also conducted with one-third of the dose combination used in the original experiments. Both ARB and ACEI inhibited neointima formation without any blood pressure changes. The full-dose combination lowered blood pressure and suppressed neointima formation significantly compared with the levels in the groups treated with either ACEI or ARB alone. The low-dose combination without blood pressure reduction also inhibited neointima formation to a similar extent as the full-dose combination. We measured 8-iso-prostaglandin F<SUB>2α</SUB> (8-iso-PGF<SUB>2α</SUB>), a marker of oxidative stress, and nitrite and nitrate (NO<SUB><I>x</I></SUB>), an index of nitric monoxide production, in media conditioned by the injured artery. NO<SUB><I>x</I></SUB> production was lower and 8-iso-PGF<SUB>2α</SUB> was higher in the media of the injured artery, compared with those in the normal artery. ACEI restored NO<SUB><I>x</I></SUB> production more dramatically than ARB, and ARB suppressed 8-iso-PGF<SUB>2α</SUB> markedly compared with ACEI. These results suggest that the combination of an ARB and an ACEI exerts an additive inhibitory effect, presumably through an increase in production and bioavailability of NO from the endothelium. (<I>Hypertens Res</I> 2004; 27: 129-135)</B>

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  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 27(2), 129-135, 2004-02-01

    The Japanese Society of Hypertension

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各種コード

  • NII論文ID(NAID)
    10012843678
  • NII書誌ID(NCID)
    AA10847079
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09169636
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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