Effect of the Growth Factors, Adenosine and ATP on the Proliferation of Human Periodontal Ligament Fibroblast

• Watanabe Keiko

  Department of Pediatric Dentistry, Osaka Dental University

• Shirasu Shinya

  Department of Pediatric Dentistry, Osaka Dental University

• Daito Michiharu

  Department of Pediatric Dentistry, Osaka Dental University

Bibliographic Information

Other Title

• 歯根膜由来線維芽細胞の増殖能に対する増殖因子,adenosineおよびATPの影響

Abstract

To investigate the role of growth factors in the proliferation of human periodontal ligament fibroblasts (HPLF), we evaluated the influence of The insulin-like growth factor- I (IGF- I ) and The plate-derived growth factor (PDGF). Furthermore, we evaluated the effects of adenosine and ATP, which are abundant during bleeding, on the proliferation of HPLF.<BR>When IGF- I and PDGF were incubated for 24 and 72 hours, concentration-dependent increases were demonstrated on the HPLF proliferation. On the other hand, when adenosine and ATP were added to HPLF, significant decreases in the cellular proliferation ability were detected at a concentration of 5×10^-4M. Thereafter, adenosine and ATP prevented potentiation of proliferation with IGF- I. In contrast, adenosine and ATP did not prevent potentiation of proliferation by PDGF. These results suggested increases in the proliferation of HPLF with IGF- I and PDGF, and the suppression abilities of adenosine and ATP on the proliferation of HPLF.

Journal

• The Japanese Journal of Pediatric Dentistry

  The Japanese Journal of Pediatric Dentistry 42 (1), 36-44, 2004

  The Japanese Society of Pediatric Dentistry

Keywords

• Fibroblast
• IGF- I
• PDGF
• Adenosine
• ATP

Details

• CRID: 1390001204686654080
• NII Article ID: 130004634552
• NII Article ID: 10012844605
• NII Book ID: AN00116228
• DOI: 10.11411/jspd1963.42.1_36
• ISSN: 05831199
• Web Site: https://search.jamas.or.jp/link/ui/2004198850
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed