小児歯肉におけるヒトβ ディフェンシン-1,-2,-3mRNAの発現および局在

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  • Expression and Localization of Human β- defensin-1, -2 and -3 mRNA in Gingival Tissue of Children

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Human β- defensins (hBDs) are a group of antimicrobial peptide mainly expressed in the epithelial cells of many organs including squamous and glandular epithelia. hBD-1, -2 and -3 have been detected in oral epithelium, consistent with their function as a protective barrier to resist bacterial infection in the oral cavity. The present study investigated the localization pattern and expression level of the hBDs mRNA in gingival tissue using the surgical discards of children. With in situ hybridization, the hBD-1, -2 and -3 mRNA were detected in the upper spinous and granular layer. The expression levels were quantified using a real-time PCR method. No significant difference in the expression level was observed between hBDs. The results show the same pattern of localization and level of expression on hBD-1, -2 and -3 mRNA, indicating that the hBDs may function together in gingival tissues.

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