New perspectives on tooth development and the dental stem cell niche

• Harada Hidemitsu

  Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry

• Ohshima Hayato

  Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences

抄録

Adult stem cells have the capacity to self-renew and differentiate along multiple lineages in addition to contributing to ongoing tissue maintenance and regeneration after injury. They reside in specific locations called stem cell niches. In biology of the tooth, the discovery of dental epithelial stem cells in continuously growing teeth has been a recent breakthrough. The niche for the adult stem cells of these teeth is formed at the region of the apical end in tooth development. The region possesces a commonly specialized histological structure for the maintenance of adult stem cells and the production of various progenitor cells producing dental tissues. The molecular signals regulating the maintenance and cell fate decision of adult stem cells, such as Notch1, Lunatic fringe, fibroblast growth factor (FGF)-10, are expressed in the epithelial structure and the surrounding mesenchyme. Based on histological and molecular biological studies, we propose a new concept that the eternal tooth buds producing various dental progeny are formed at the apical end in the development of continuously growing teeth, and coin a new term of “apical bud” for indicating this specialized epithelial structure. Furthermore, the relationship between signaling centers and the expression of FGF-10 mRNA as the determinant of morphogenesis is discussed with an emphasis on tooth and limb development, taking note that the expression pattern of FGF-10 is an important key for understanding the mechanisms for the diversity of cusp patterns and between continuous and limited growth.

収録刊行物

• Ａｒｃｈｉｖｅｓ　ｏｆ　Ｈｉｓｔｏｌｏｇｙ　ａｎｄ　Ｃｙｔｏｌｏｇｙ

  Ａｒｃｈｉｖｅｓ　ｏｆ　Ｈｉｓｔｏｌｏｇｙ　ａｎｄ　Ｃｙｔｏｌｏｇｙ 67 (1), 1-11, 2004

  国際組織細胞学会

キーワード

• Histology

詳細情報

• CRID: 1390282681388435072
• NII論文ID: 130004462623
• NII論文ID: 10012846300
• NII書誌ID: AA1068990X
• DOI: 10.1679/aohc.67.1
• COI: 1:STN:280:DC%2BD2c3is1Wntw%3D%3D
• ISSN: 13491717
• ISSN: 09149465
• PubMed: 15125018
• Web Site: http://www.jstage.jst.go.jp/article/aohc/67/1/67_1_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2005245869
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可