Stably-dispersed and Surface-functional Bionanoparticles Prepared by Self-assembling Amphipathic Polymers of Hydrophilic Poly(γ-glutamic acid) Bearing Hydrophobic Amino Acids

DOI PDF 被引用文献23件 参考文献45件
  • Michiya Matsusaki
    Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University
  • Ken-ichiro Hiwatari
    Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University
  • Mariko Higashi
    Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University
  • Tatsuo Kaneko
    Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University
  • Mitsuru Akashi
    Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University

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<jats:title>Abstract</jats:title> <jats:p>Surface-functional bionanoparticles were prepared by self-assembling amphipathic poly(γ-glutamic acid) derivatives with a hydrophilic backbone and hydrophobic phenylalanine and leucine side groups. Poly(γ-glutamic acid) bearing phenylalanine nanospheres exhibited excellent water-dispersibility, surface functionality and appropriate size (200 nm) for medical use. Additive PEG conjugation assisted nanoparticle formation of leucine-grafted poly(γ-glutamic acid).</jats:p>

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  • Chemistry Letters

    Chemistry Letters 33 (4), 398-399, 2004-03-06

    Oxford University Press (OUP)

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