Synthesis and Physical Nature of Fluorescent Photoaffinity Probe for the Bioorganic Studies on Tautomycin, a Protein Phosphatase Type 1 Selective Inhibitor

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Author(s)

Abstract

Fluorescent photoaffinity probe, which possesses a dansyl amide functional group on the maleic moiety of tautomycin, was prepared in order to detect the trace amount of labeled peptides. The parent compound dramatically showed fluorescence quenching before the photoreaction due to the exciplex formation on the basis of the folded conformation. Several benzhydrol analogs, on the other hand, recovered the strong fluorescence; thus, this system could be employed for the photoaffinity labeling studies.

Journal

  • Chemistry Letters

    Chemistry Letters 33(4), 452-453, 2004-04-05

    The Chemical Society of Japan

References:  11

Codes

  • NII Article ID (NAID)
    10012847370
  • NII NACSIS-CAT ID (NCID)
    AA00603318
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    03667022
  • Data Source
    CJP  J-STAGE 
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