Aluminum Facilitation of the Iron-Mediated Oxidation of DOPA to Melanin

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著者

    • Di Junwei DI Junwei
    • Department of Chemistry, State Key Laboratory of Coordination Chemistry of China, Nanjing University
    • Bi Shuping BI Shuping
    • Department of Chemistry, State Key Laboratory of Coordination Chemistry of China, Nanjing University

抄録

Aluminum, a trivalent cation unable to undergo redox reactions, is shown to faciliate iron-initiated DOPA oxidation in the melanin pathway under acidic condition of pH 5.5, which is a favored medium for aluminum facilitation of iron-induced lipid peroxidation. In the process of oxidation of DOPA to melanin in the presence of the metal ions, Fe<sup>3+</sup> and H<sub>2</sub>O<sub>2</sub> oxidize DOPA to dopachrome (DC), then Al<sup>3+</sup> catalyzes the conversion of DC to 5,6-dihydroxyindole (DHI) and finally Fe<sup>3+</sup> oxidizes DHI to indole-5,6-quinone (IQ), which polymerizes immediately to melanochrome and melanin. The reactions involve the intermediate complexes of metal ions and DOPA or its derivative. The present results indicate that aluminum can enhance the oxidative stress on iron-mediated DOPA oxidation in melanin pathway under acidic condition through the cooperation of iron and aluminum ions.

収録刊行物

  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20(4), 629-634, 2004-04-10

    The Japan Society for Analytical Chemistry

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各種コード

  • NII論文ID(NAID)
    10012850620
  • NII書誌ID(NCID)
    AA10500785
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09106340
  • NDL 記事登録ID
    6912001
  • NDL 雑誌分類
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL 請求記号
    Z54-F482
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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