アジン系複素環化合物の合成とそれらの機能性分子への変換 Synthesis of Azine-type Heterocyclic Compounds and Their Conversion into Functional Molecules

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著者

    • 加藤 明良 KATOH Akira
    • 成蹊大学工学部応用化学科 Department of Applied Chemistry, Faculty of Engineering, Seikei University
    • 齋藤 良太 SAITO Ryota
    • 成蹊大学工学部応用化学科 Department of Applied Chemistry, Faculty of Engineering, Seikei University

抄録

We have focused on the synthesis of azine-type heterocyclic compounds and their conversion into useful functional molecules. In this article, the following points were reviewed. 1) 6-Amino-2, 3-dimorpholinoquinoxalines bearing the amino acid residues at C-6 position were found to be highly-sensitive fluorescent chiral derivatization reagents. 2) A new tripodal heterocyclic hexadentate ligand, in which three sets of 3-hydroxy-4 (1<I>H</I>) -pyridinone and ethyleneoxy chain are linked to tris (carboxyethoxymethyl) ethane was synthesized. The allosteric binding of alkali metal ions to a pseudocryptand formed by the ligand and Ga (III) was discussed. 3) Hydroxyazine-type linear and cyclic hexapeptides were newly synthesized. The iron (M) complex-forming tendency, the absolute configuration, the stability constant, the iron (III) removal from human transferrin, and the growth-promotion activity were discussed. 4) Oxovanadium complexes of 3-hydroxy-4 (1<I>H</I>) -pyridinones were synthesized. The spectroscopic characterization of the complexes was carried out on the basis of <SUP>1</SUP>H-, <SUP>51</SUP>V-NMR, IR, UV-VIS, FAB MS, ESI MS and ESR spectra, and cyclic voltammetry (CV). Further, an extremely high insulin-mimetic activity of bis (1, 4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato) zinc (II) complex was also discussed.

収録刊行物

  • 有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN

    有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN 62(4), 335-346, 2004-04-01

    The Society of Synthetic Organic Chemistry, Japan

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各種コード

  • NII論文ID(NAID)
    10012854842
  • NII書誌ID(NCID)
    AN0024521X
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00379980
  • NDL 記事登録ID
    6918411
  • NDL 雑誌分類
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL 請求記号
    Z17-256
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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