ＣＯＸと消化器疾患

• 辻井 正彦

  大阪大学大学院医学系研究科病態情報内科学

書誌事項

タイトル別名

• COX and Gastrointestinal Diseases.

抄録

One of severe side effects of nonsteroidal anti-inflammatory drugs (NSAIDs) is gastroduodenal mucosal damage. Cyclooxygenase is one of molecular targets of NSAIDs, and one of the isozymes, COX-2 is reported to be highly expressed in inflammatory tissues. As a candidate of the most safe and effective anti-inflammatory drug, COX-2 specific inhibitors have been developed. On the other hand, it is also reported that COX-2 is upregulated in cancer tissues and NSAIDs affects biology of many kinds of cancer. Therefore, to investigate possible indication of NSAIDs and COX-2 specific inhibitors in anti-cancer therapy, a lot of researches have been under way.

収録刊行物

• 日本消化器内視鏡学会雑誌

  日本消化器内視鏡学会雑誌 46 (1), 3-10, 2004

  一般社団法人 日本消化器内視鏡学会

キーワード

• 粘膜障害
• 消化器癌

詳細情報

• CRID: 1390282679191944960
• NII論文ID: 130004254686
• NII論文ID: 10012863608
• NII書誌ID: AN00192102
• DOI: 10.11280/gee1973b.46.3
• ISSN: 18845738
• ISSN: 03871207
• Web Site: https://search.jamas.or.jp/link/ui/2004158118
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可