COX and Gastrointestinal Diseases.

• TSUJII Masahiko

  Osaka University Graduate School of Medicine Department of Internal Medicine and Therapeutics

Bibliographic Information

Other Title

• ＣＯＸと消化器疾患

Abstract

One of severe side effects of nonsteroidal anti-inflammatory drugs (NSAIDs) is gastroduodenal mucosal damage. Cyclooxygenase is one of molecular targets of NSAIDs, and one of the isozymes, COX-2 is reported to be highly expressed in inflammatory tissues. As a candidate of the most safe and effective anti-inflammatory drug, COX-2 specific inhibitors have been developed. On the other hand, it is also reported that COX-2 is upregulated in cancer tissues and NSAIDs affects biology of many kinds of cancer. Therefore, to investigate possible indication of NSAIDs and COX-2 specific inhibitors in anti-cancer therapy, a lot of researches have been under way.

Journal

• GASTROENTEROLOGICAL ENDOSCOPY

  GASTROENTEROLOGICAL ENDOSCOPY 46 (1), 3-10, 2004

  Japan Gastroenterological Endoscopy Society

Keywords

• NSAIDs

Details

• CRID: 1390282679191944960
• NII Article ID: 130004254686
• NII Article ID: 10012863608
• NII Book ID: AN00192102
• DOI: 10.11280/gee1973b.46.3
• ISSN: 18845738
• ISSN: 03871207
• Web Site: https://search.jamas.or.jp/link/ui/2004158118
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed