胃癌における Docetaxel および Doxifluridine による thymidine phosphorylase と dihydropyrimidine dehydrogenase の発現誘導 INDUCTION OF TP AND DPD EXPRESSION BY DOCETAXEL AND DOXIFLURIDINE (5'-DFUR) IN GASTRIC CANCER

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著者

    • 梅本 淳 UMEMOTO Atsushi
    • 徳島大学医学部病態制御外科 Department of Surgery and Clinical Oncology, The University of Tokushima School of Medicine
    • 本田 純子 HONDA Junko
    • 徳島大学医学部病態制御外科 Department of Surgery and Clinical Oncology, The University of Tokushima School of Medicine
    • 沖津 奈都 OKITSU Natsu
    • 徳島大学医学部病態制御外科 Department of Surgery and Clinical Oncology, The University of Tokushima School of Medicine
    • 清家 純一 SEIKE Junichi
    • 徳島大学医学部病態制御外科 Department of Surgery and Clinical Oncology, The University of Tokushima School of Medicine
    • 谷田 信行 TANIDA Nobuyuki
    • 徳島大学医学部病態制御外科 Department of Surgery and Clinical Oncology, The University of Tokushima School of Medicine
    • 門田 康正 MONDEN Yasumasa
    • 徳島大学医学部病態制御外科 Department of Surgery and Clinical Oncology, The University of Tokushima School of Medicine

抄録

Doxifluridine (5'-DFUR)が効率良く5-FUに変換されるためにはthymidine phosphorylase (TP)の発現が誘導される必要がある.進行胃癌を対象にDocetaxel (TXT)および5'-DFURによるTP・dihydropyrimidine dehydrogenase (DPD)の発現誘導を検討した.研究1 (n=11)はTXT 20mg投与前および1週後の癌および正常粘膜のTP, DPD量を測定した.研究2 (n=14)は5'-DFUR 1,200mg/日2日間投与前後の癌および正常粘膜のTP, DPD量を測定し,同患者に対しTXT 40mgおよびその5日後より5'-DFUR 1,200mg/日2日間投与しTXT投与1週後の癌および正常粘膜のTP, DPD量を測定した.癌組織のTP発現はTXT 40mg投与により誘導された(p=.0052)が,正常粘膜のTPは変動しなかった. DPD発現はTXT投与により癌組織では影響を受けなかったが,正常粘膜では40mg投与で低下(p=.0092)した. TP/DPD比はTXT投与により癌組織で上昇した(p=.0303).癌および正常粘膜におけるTP, DPDの発現は5'-DFUR投与による影響を受けなかった.胃癌症例においてTXTと5'-DFURの併用は相乗的な抗腫瘍効果の増強が期待できる.

For doxifluridine (5'-DFUR) to be efficiently converted to 5-FU, it is necessary for thymidine phosphorylase (TP) expression to be induced. We investigated the effects of docetaxel (TXT) and 5'-DFUR on the induction of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) expression in postoperative cases of advanced gastric cancer. In Study 1 (n=11), the TP and DPD levels in cancer tissue and normal mucosa were measured before and 1 week following a single administration of TXT 20mg. In Study 2 (n=14), the TP and DPD levels in cancer tissue and normal mucosa were measured before and after the administration of 5'-DFUR 1200mg/day for 2 days. Then, in the same patient group, TXT 40mg, and 5days later 5'-DFUR 1200mg/day for 2 days, were administered and the TP and DPD levels in cancer tissue and normal mucosa were measured 1 week after administration of TXT. TP expression was induced in cancer tissue by administration of TXT 40mg (p=0.0052), whereas TP expression in normal mucosa was unchanged. The expression of DPD in cancer tissue was unaffected by TXT administration, but it was decreased following the administration of 40mg TXT in normal mucosa (p=0.0092). The TP/DPD ratio in cancer tissue was increased by TXT administration (p=0.0303). The administration of 5'-DFUR did not affect the TP and DPD levels in cancer tissue and normal mucosa. Concomitant use of TXT and 5'-DFUR can be expected to synergistically potentiate individual anti-tumor effects in cases of gastric cancer.

収録刊行物

  • 日本臨床外科学会雑誌 = The journal of the Japan Surgical Association

    日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 65(3), 587-593, 2004-03-25

    Japan Surgical Association

参考文献:  19件中 1-19件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10012864897
  • NII書誌ID(NCID)
    AA11189709
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    13452843
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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