Efficiency of Rebamipide in the Prevention of Remnant Gastritis after Distal Gastrectomy
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- FUKUHARA Kenichiro
- Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine
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- OSUGI Harushi
- Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine
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- TAKEMURA Masashi
- Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine
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- MORIMURA Keiichiro
- Department of Pathology, Osaka City University Graduate School of Medicine
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- LEE Shigeru
- Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine
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- KANEKO Masahiro
- Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine
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- TANAKA Yoshinori
- Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine
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- FUJIWARA Yushi
- Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine
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- NISHIZAWA Satoshi
- Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine
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Background/Aims :The role of rebamipide administration in reducing remnant gastritis after distal gastrectomy was studied.<BR>Patients :Among patients with gastric cancer who underwent macroscopically curative distal gastrectomy with Roux-Y reconstruction in our department between July 1999 and September 2001, 22 subjects without particular complications were analyzed in the study. The patients were randomly divided into two groups. Eleven patients (Group A) were orally administered 300 mg/day of a gastroprotective agent, rebamipide (Mucosta) for 12 weeks starting at one week postoperatively. Treatment by administration of anti-acids or any agent possibly affecting the gastric mucosa or gastric emptying was prohibited in the other 11 patients (Group B).<BR>Methods :All patients underwent endoscopic biopsy within 2 weeks before the operation and 13 weeks after the operation. Histological gastritis and IL-8 concentration in the gastric mucosa was also examined.<BR>Results :The degree of neutrophil infiltration decreased after operation in both groups. The decrease was more remarkable in Group A than in Group B (p=0.02). IL-8 concentration in the gastric mucosa was reduced by administration of rebamipide, and its manifestation was significantly accelerated by H. pylori infection (p=0.03).<BR>Conclusions :Administration of the gastroprotective agent, rebamipide appears to be histochemically effective in suppressing remnant gastritis after distal gastrectomy.
収録刊行物
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- 日本外科系連合学会誌
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日本外科系連合学会誌 29 (2), 192-196, 2004
日本外科系連合学会
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詳細情報 詳細情報について
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- CRID
- 1390001204348500224
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- NII論文ID
- 10012877702
- 130006790680
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- NII書誌ID
- AN00002502
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- ISSN
- 18829112
- 03857883
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可