ラット腹膜炎モデルにおけるポリミキシンＢ固定化ファイバー（ＰＭＸ‐Ｆ）を用いた腹膜潅流の有用性の検討

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  • Effects of Peritoneal Dialysis Using a Polymyxin-B Immobilized Fiber Column on the Inflammatory Responses in a Rat Experimental Peritonitis Model

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Hypercytokinemia, an important cause of systemic inflammatory response syndrome is considered to result from local production of inflammatory cytokines at the inflammation site. We used a rat experimental peritonitis model to test whether locally produced cytokines could be eliminated by peritoneal dialysis using a polymyxin-B immobilized fiber column (PMX-F). The experimental peritonitis model in rats was produced by cecal ligation and puncture, and animals were assigned to 2 experimental groups i. e., 1 group undergoing peritoneal dialysis with PMX-F (PMX-F groups) and 1 without PMX-F (controls) 3 h after peritonitis induction. The concentration of IL-6 and IL-10 in ascitic fluid in rats with peritonitis in the PMX-F group was significantly lower than in controls. In addition to the fact that locally produced inflammatory cytokines induced apoptosis of neutrophils indirectly prevents tissue injury, the elimination of cytokines can prevent the inflammatory response that occurred in peritonitis and prevent ultimate progression into multiple organ dysfunction syndrome. These results suggest that peritoneal dialysis with the PMX-F column in early septic insult may help prevent hypercytokinemia and resultant SIRS / MODS.

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