Synthesis of HIV Vaccine Model Based on Lactose-Functionalized Poly(lysine) Dendrimer Scaffold

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  • Baigude Huricha
    Department of Enviromental and Material Engineering, Teikyo Unuversity of Science & Technology
  • Katsuraya Kaname
    Wayo Womens' University
  • Okuyama Kohsaku
    Institute of Industrial Science, University of Tokyo
  • Kariya Naoki
    Department of Enviromental and Material Engineering, Teikyo Unuversity of Science & Technology
  • Uryu Toshiyuki
    Department of Enviromental and Material Engineering, Teikyo Unuversity of Science & Technology

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Abstract

A series of HIV vaccine models based on lactose-bound poly(lysine) scaffolds was synthesized. A spherical poly(lysine) dendrimer was prepared to bind lactose at the peripheral through reductive amination. Lactose-poly(lysine) dendrimers with the degree of substitution (DS) varying from 5 to 19 were obtained by controlling the feeding ratio of lactose to the poly(lysine) dendrimer. Three succinylated compounds such as succinyl monobenzylate, ethyl-phenylalanyl succinylamide and succinyl-L-alanyl-L-prolyl-L-alanine p-nitroanilide which were regarded as antigen peptide models were bound to the lactose-poly(lysine) dendrimer through esterification between the carboxyl group of the succinyl moiety and the 6-OH group of the lactose residue. The DS of resulting vaccine models was investigated by NMR spectra analyses.

Journal

  • Sen'i Gakkaishi

    Sen'i Gakkaishi 60 (4), 118-124, 2004

    The Society of Fiber Science and Technology, Japan

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