Comparison of the disposition of organic anions in an animal model for Wilson's disease (Long-Evans Cinnamon rat) with that in normal Long-Evans Agouti rats

• ITAGAKI Shirou

  Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University

• SUGAWARA Mitsuru

  Department of Pharmacy, Hokkaido University Hospital

• KOBAYASHI Michiya

  Department of Pharmacy, Hokkaido University Hospital

• MIYAZAKI Katsumi

  Department of Pharmacy, Hokkaido University Hospital

• HIRANO Takeshi

  Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University

• ISEKI Ken

  Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University

書誌事項

タイトル別名

• Comparison of the Disposition Behavior of Organic anions in an Animal Model for Wilson's Disease (Long-Evans Cinnamon rats) with that in Normal Long-Evans Agouti rats

抄録

  Long-Evans Cinnamon (LEC) rats have an abnormality similar to that observed in Wilson's disease in humans and are therefore a good animal model for the study of Wilson's disease. LEC rats develop hereditary hepatitis and severe jaundice. Mutant animals with hyperbilirubinemia have been widely used as animal models for human diseases. Among these mutant animals, Eisai hyperbilirubinemic rats (EHBR) have defective biliary excretion of organic anions. Thus, biliary excretion of sulfobromophthalein (BSP) and urinary excretion of phenolsulfonphthalein (PSP) in LEC rats were compared with those in Long-Evans Agouti (LEA) rats. In LEC rats, the excretion of BSP, a multidrug resistance-associated protein 2 (Mrp2/Abcc2) substrate, was significantly decreased compared to that in LEA rats. It has been reported that the transport function for organic anions on the kidney is maintained in EHBR. However, the urinary excretion of PSP is impaired in LEC rats. It is possible that organic anion transporters responsible for the urinary excretion of PSP in LEA rats and EHBR are impaired in LEC rats. It is important to elucidate the relationship between organic anion secretion and Wilson's disease.<br>

収録刊行物

• Ｄｒｕｇ　Ｍｅｔａｂｏｌｉｓｍ　ａｎｄ　Ｐｈａｒｍａｃｏｋｉｎｅｔｉｃｓ

  Ｄｒｕｇ　Ｍｅｔａｂｏｌｉｓｍ　ａｎｄ　Ｐｈａｒｍａｃｏｋｉｎｅｔｉｃｓ 19 (2), 150-154, 2004

  日本薬物動態学会

キーワード

• Long-Evans Cinnamon rats
• transporter
• urinary excretion
• organic anion
• Wilson's disease

詳細情報

• CRID: 1390282680157685888
• NII論文ID: 10012923692
• NII書誌ID: AA1162652X
• DOI: 10.2133/dmpk.19.150
• ISSN: 18800920
• ISSN: 13474367
• PubMed: 15499181
• Web Site: http://api.elsevier.com/content/article/PII:S1347436715308090?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S1347436715308090?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2005000559
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可