結核性胸膜炎の診断と治療－とくに胸水中サイトカイン測定の意義について－

• 青江 啓介

  国立療養所山陽病院呼吸器科 国立療養所山陽病院臨床研究部 独立行政法人国立病院機構山陽病院

• 平木 章夫

  国立療養所山陽病院呼吸器科 独立行政法人国立病院機構山陽病院

• 村上 知之

  国立療養所山陽病院臨床研究部 独立行政法人国立病院機構山陽病院

書誌事項

タイトル別名

• DIAGNOSIS AND TREATMENT OF TUBERCULOUS PLEURISY-With Special Reference to the Significance of Measurement of Pleural Fluid Cytokines-
• ケッカクセイ キョウマクエン ノ シンダン ト チリョウ : トクニ キョウスイ チュウ サイトカイン ソクテイ ノ イギ ニ ツイテ
• With Special Reference to the Significance of Measurement of Pleural Fluid Cytokines
• とくに胸水中サイトカイン測定の意義について

抄録

Tuberculous pleurisy as well as malignant pleuritisis a representative disease presenting pleural effusion. Thediagnosis of tuberculous pleurisy is made from examinationof pleural effusion, but the sensitivity of smear or culture ofMycobacterium tuberculosis from pleural fluid is generally low.Although the pleural fluid concentration of adenosine deaminase (ADA) is useful in terms of sensitivity or specificity, the value could be high in empyema or rheumatoid pleuritis.Thoracoscopic biopsy of pleura is more sensitive rather thanconventional percutaneous needle biopsy, but is more invasive.Tuberculous pleural effusion is caused by delayed allergywhich macrophage and T-helper 1 cells mainly relate and thestimuli of bacterial body consecutively induces T-helper 1cytokines. Pleural fluid interferon-γ (INF-γ) is important notonly in pathogenesis but also in diagnosis. We demonstratedthat INF-γ is a more sensitive and specific indicator fortuberculous pleurisy than ADA using receiver operatingcharacteristics (ROC) analysis. Cytometric bead array (CBA) is a tool to simultaneously measure abundance of variouscytokines and is expected to be a very useful method toprovide informations for understanding a feedback mechanismof cytokine network. It is needed to clear the immunity inpleural fluid and to establish the less invasive and more usefulmethod to diagnose tuberculous pleurisy.

収録刊行物

• 結核

  結核 79 (4), 289-295, 2004

  一般社団法人 日本結核病学会

キーワード

• 結核性胸膜炎
• 診断
• サイトカイン
• ROC曲線

詳細情報

• CRID: 1390282679977716480
• NII論文ID: 10012926089
• NII書誌ID: AN00073442
• DOI: 10.11400/kekkaku1923.79.289
• ISSN: 18842410
• ISSN: 00229776
• NDL書誌ID: 026778854
• PubMed: 15168435
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026778854
• Web Site: https://search.jamas.or.jp/link/ui/2004244360
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • PubMed
  • CiNii Articles
  • Crossref
• 抄録ライセンスフラグ: 使用不可