The Basic Research on Physiological Property of Functionalized Hyaluronan(II) : Effect of Sulfated Hyaluronan on Histamine Release from the Mast Cell

この論文にアクセスする

この論文をさがす

著者

抄録

Hyaluronan (HA) is one of polysaccharides in living body that is found widely in connective tissue of the mammals. It has no sulfate group but high molecular weight in comparison with other glycosaminoglycans (GAGs). We synthesized sulfated HA (S-HA) with various degrees of substitution (D.S.) in order to give HA new biological functions, since GAGs with sulfate groups interact with various biocomponents to express some specific biofunctions. Moreover in order to develop biomedical polymers, immunological response against artificial polymer matrices must be evaluated. So we measured histamine release from the mast cell and discussed the effect of S-HA on the immunological response. It was confirmed that they could be used as biomedical materials with immunological safety. And S-HA inhibited the histamine release that was induced by compound 48/80 from the mast cell. The inhibitory effect of S-HA was seemed to be due to such various factors as D.S., molecular weight, substitution site of the sulfate group and the structure of a polysaccharide chain.

収録刊行物

  • 繊維学会誌

    繊維学会誌 60(5), 137-143, 2004-05-10

    The Society of Fiber Science and Technology, Japan

参考文献:  21件中 1-21件 を表示

  • <no title>

    AIBA S.

    Biomaterials 8, 481, 1987

    被引用文献2件

  • <no title>

    GLEICH G. J.

    Mast Cell Differentiation and Heterogeneity 347, 1986

    被引用文献1件

  • <no title>

    OKUNO T.

    J. Immunol. 136, 4652, 1990

    被引用文献1件

  • <no title>

    STEAT R. H.

    Proc. Natl. Acad. Sci. U.S.A. 84, 2975, 1987

    被引用文献1件

  • <no title>

    JALKANEN M.

    Receptors for Extracellular Matrix 1, 1991

    被引用文献1件

  • <no title>

    NINOMIYA Y.

    J. Biochem. 86, 111, 1979

    被引用文献1件

  • <no title>

    KIKUCHI T.

    Int. J. Tissue React. 18, 87, 1996

    被引用文献1件

  • <no title>

    SAKAKIBARA Y.

    Itoh, Clin. Orthop. 299, 282, 1994

    被引用文献1件

  • <no title>

    HAMANO T.

    J. Biomed. Mater. Res. 41, 257, 1998

    被引用文献2件

  • <no title>

    HAMANO T.

    J. Biomed. Mater. Res. 41, 270, 1998

    被引用文献2件

  • <no title>

    ANDEREGG G.

    Helv. Chim. Acta 37, 113, 1954

    被引用文献2件

  • <no title>

    SHORE P. A.

    J. Pharmacal. Exp. Ther. 127, 182, 1959

    被引用文献1件

  • <no title>

    HAMANO T.

    J. Biomater. Sci. Polym. Ed. 9, 985, 1998

    被引用文献1件

  • <no title>

    SEARS P.

    Proc. Natl. Acad. Sci. USA 93, 12086, 1991

    DOI 被引用文献2件

  • <no title>

    MEADE CJ

    Life Sci. 69, 1225, 2001

    被引用文献2件

  • <no title>

    MATSUDA H.

    J. Immunol. 144, 259, 1990

    被引用文献7件

  • <no title>

    YURT R. W.

    J. Biol. Chem. 252, 518-521, 1977

    被引用文献7件

  • <no title>

    NIITSUMA A.

    Gen. Pharmacol. 27, 123, 1996

    被引用文献1件

  • <no title>

    GHOSH TK.

    J. Biol. Chem. 263, 11075-11079, 1988

    被引用文献9件

  • <no title>

    TONES M. A.

    FEBS Lett. 252, 105, 1989

    被引用文献1件

  • Interactions between macromolecules in solution and intermacromolecular complexes

    TSUCHIDA E.

    Adv. Polym. Sci. 45, 1-119, 1982

    被引用文献6件

各種コード

  • NII論文ID(NAID)
    10012933384
  • NII書誌ID(NCID)
    AN00131651
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00379875
  • NDL 記事登録ID
    6951276
  • NDL 雑誌分類
    ZP33(科学技術--繊維工学・工業)
  • NDL 請求記号
    Z17-189
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ