Biphasic Regulation of Fc-Receptor Mediated Phagocytosis of Rabbit Alveolar Macrophages by Surfactant Phospholipids

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著者

    • MORITO TOSHIHIRO
    • Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
    • OISHI KAZUNORI
    • Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
    • YAMAMOTO MASASHI
    • Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
    • MATSUMOTO KEIZO
    • Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University

抄録

Dipalmitoyl phosphatidylcholine (DPPC) is a major phospholipid constituent in the pulmonary surfactant, whereas lysophosphatidylcholine (Lyso-PC) is a minor constituent, this membrane phospholipid being produced at inflammatory sites in association with activation of phospholipase A<sub>2</sub>. To determine the role of these two different forms of phospholipids in the phagocytic function of alveolar macrophages (AM), we examined the effects of DPPC or Lyso-PC on Fc-mediated phagocytosis. We demonstrated a significant decrease of the ingestion activity of AM for anti-sheep erythrocyte immunoglobulin G-coated sheep erythrocytes (EA: IgG) by DPPC. On the other hand, Lyso-PC caused significantly increased ingestion of EA: IgG by AM. These data indicate that increase of Lyso-PC due to the hydrolysis of DPPC through activation of phospholipase A<sub>2</sub> may up-regulate AM-mediated phagocytic functions in the alveolar milieu associated with infections and inflammation. DPPC may suppress and stabilize the AM-mediated phagocytosis in the normal alveolar environment.

収録刊行物

  • THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

    THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 190(1), 15-22, 2000-01-01

    Tohoku University Medical Press

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各種コード

  • NII論文ID(NAID)
    10013014333
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  J-STAGE 
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