Auto Iris Pigment Epithelial Cell Transplantation in Patients with Age-Related Macular Degeneration: Short-Term Results

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  • Abe Toshiaki
    Department of Ophthalmology, Tohoku University, School of Medicine
  • Yoshida Madoka
    Department of Ophthalmology, Tohoku University, School of Medicine
  • Tomita Hiroshi
    Department of Ophthalmology, Tohoku University, School of Medicine
  • Kano Tetsuya
    Department of Ophthalmology, Tohoku University, School of Medicine
  • Sato Masami
    Department of Ophthalmology, Tohoku University, School of Medicine
  • Wada Yuko
    Department of Ophthalmology, Tohoku University, School of Medicine
  • Fuse Nobuo
    Department of Ophthalmology, Tohoku University, School of Medicine
  • Yamada Tasuku
    Department of Ophthalmology, Tohoku University, School of Medicine
  • Tamai Makoto
    Department of Ophthalmology, Tohoku University, School of Medicine

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Abstract

Autologous iris pigment epithelial cell transplantation was performed on patients with exudative age-related macular degeneration (AMD). Autologous IPE cell culture was performed using autologous serum after iridectomy in 7 patients with AMD. The cell suspensions (2∼20×104 cells) were transplanted into the submacular lesion of individuals after removal of neovascular membranes. Subsequent ophthalmological examinations, including best corrected visual acuity and fluorescein or indocyanine green angiography, were performed. In addition, 15 patients with AMD, who underwent removal of neovascular membrane without transplantation, were evaluated as non randomized controls. Varying degrees of atrophy or defects of choriocapillaris and retinal pigment epithelium were observed in all of the patients. No cystoid macular edema or fluorescein leakage was observed after treatment, but window defects were present. No patient had decreased visual acuity. One treated patient developed mild subretinal fibrosis and an other patient developed mild preretinal fibrosis, however no difference was significant when compared with the control. In coclusion, the treatment resulted in no significant improvement in macular function, as compared with the control; however, no rejection or deterioration in visual acuity occurred up to the 13 month follow up.

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