Infiltration of CD8^+ T cells in Non-Small Cell Lung Cancer is Associated with Dedifferentiation of Cancer Cells, but not with Prognosis

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著者

    • MORI MASUKO
    • Department of Pathology, Aging and Cancer, Tohoku University
    • OHTANI HARUO
    • Department of Pathology, Tohoku University School of Medicine
    • SAGAWA MOTOYASU
    • Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
    • SATO MASAMI
    • Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
    • FUJIMURA SHIGEFUMI
    • Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University

抄録

CD8<sup>+</sup> T cells infiltrating within cancer cell nests in human colorectal cancer were associated with a favorable patients' survival, suggesting the presence of anti-tumor immunity. The present study was designed to examine this concept in non-small cell lung cancer (NSCLC) by a retrospective analysis of 128 surgically resected cases. Immunohistochemical analysis showed that the number of CD8<sup>+</sup> T cells within cancer cell nests in NSCLC was related to the histological subtype (large cell carcinoma or squamous cell carcinoma>adenocarcinoma) and the degree of dedifferentiation (undifferentiated type>differentiated type). In contrast to colorectal cancer, the number of CD8<sup>+</sup> T cells in NSCLC had no statistically significant impact on the patients' survival. The present study demonstrated that the degree of infiltration of CD8<sup>+</sup> T cells within cancer cell nests is dependent on the dedifferentiation of cancer cells in NSCLC, which could be one of the important aspects for the study of tumor immunity.

収録刊行物

  • THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

    THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 191(2), 113-118, 2000-06-01

    東北ジャーナル刊行会

参考文献:  16件中 1-16件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10013015186
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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