Infiltration of CD8+ T cells in Non-Small Cell Lung Cancer is Associated with Dedifferentiation of Cancer Cells, but not with Prognosis

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  • Mori Masuko
    Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University
  • Ohtani Haruo
    Department of Pathology, Tohoku University School of Medicine
  • Naito Yoshitaka
    Department of Pathology, Tohoku University School of Medicine
  • Sagawa Motoyasu
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
  • Sato Masami
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
  • Fujimura Shigefumi
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
  • Nagura Hiroshi
    Department of Pathology, Tohoku University School of Medicine

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CD8+ T cells infiltrating within cancer cell nests in human colorectal cancer were associated with a favorable patients' survival, suggesting the presence of anti-tumor immunity. The present study was designed to examine this concept in non-small cell lung cancer (NSCLC) by a retrospective analysis of 128 surgically resected cases. Immunohistochemical analysis showed that the number of CD8+ T cells within cancer cell nests in NSCLC was related to the histological subtype (large cell carcinoma or squamous cell carcinoma>adenocarcinoma) and the degree of dedifferentiation (undifferentiated type>differentiated type). In contrast to colorectal cancer, the number of CD8+ T cells in NSCLC had no statistically significant impact on the patients' survival. The present study demonstrated that the degree of infiltration of CD8+ T cells within cancer cell nests is dependent on the dedifferentiation of cancer cells in NSCLC, which could be one of the important aspects for the study of tumor immunity.

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