水道水中の強力な変異原物質 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) の分布と毒性  [in Japanese] Distribution of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in Water Samples, and Its Chemical and Genotoxic Properties  [in Japanese]

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Author(s)

    • 杉山 千歳 SUGIYAMA Chitose
    • 静岡県立大学大学院生活健康科学研究科 Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
    • 中嶋 圓 NAKAJIMA Madoka
    • 静岡県立大学大学院生活健康科学研究科 Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
    • 増田 修一 MASUDA Shuichi
    • 静岡県立大学大学院生活健康科学研究科 Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
    • 大石 悦男 OISHI Etsuo
    • 静岡県立大学大学院生活健康科学研究科 Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
    • 木苗 直秀 KINAE Naohide
    • 静岡県立大学大学院生活健康科学研究科 Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

Abstract

Various mutagens and carcinogens are formed during the chlorine disinfection of raw drinking water. Among them, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5<i>H</i>)-furanone (MX), exhibits a high mutagenic activity against <i>Salmonella typhimurium</i> TA100 without S9 mix, which is comparable to aflatoxin B<sub>1</sub>. Recently, it has been demonstrated that MX induces stomach tumor to rats in the 2-stage carcinogenicity test using <i>N</i>-methyl-<i>N'</i>-nitro-<i>N</i>-nitrosoguanidine (MNNG). In this review, we summarize the distribution of MX in several water samples including drinking water and its chemical, biological and genotoxic properties.

Journal

  • Journal of Japan Society on Water Environment

    Journal of Japan Society on Water Environment 27(6), 393-401, 2004-06-10

    Japan Society on Water Environment

References:  111

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Codes

  • NII Article ID (NAID)
    10013080006
  • NII NACSIS-CAT ID (NCID)
    AN10372439
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    09168958
  • NDL Article ID
    6986372
  • NDL Source Classification
    ZN5(科学技術--建設工学・建設業--都市工学・衛生工学)
  • NDL Call No.
    Z16-1045
  • Data Source
    CJP  NDL  J-STAGE 
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