Assessment of Myocardial Creatine Concentration in Dysfunctional Human Heart by Proton Magnetic Resonance Spectroscopy

• NAKAE Ichiro

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• MITSUNAMI Kenichi

  Department of General Medicine, Shiga University of Medical Science

• MATSUO Shinro

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• MATSUMOTO Tetsuya

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• MORIKAWA Shigehiro

  Molecular Neuroscience Research Center, Shiga University of Medical Science

• INUBUSHI Toshiro

  Molecular Neuroscience Research Center, Shiga University of Medical Science

• KOH Terue

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• HORIE Minoru

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

Abstract

Creatine depletion in the non-viable infarcted human heart was previously demonstrated with proton magnetic resonance (MR) spectroscopy (¹H MRS). In the present study, we assessed total creatine (CR) in human hearts with non-ischemic dysfunctions such as cardiomyopathy. Using cardiac-gated ¹H MRS with MR image-guided PRESS localization, we measured septal CR in healthy and diseased human hearts. Fifteen patients with chronic heart failure (CHF, left ventricular ejection fraction <45%) and 14 age-matched normal subjects were examined. Myocardial CR was significantly (p<0.001) lower in failing hearts (15.1±SD 5.0 μmol/g wet weight, range 8.0-22.9) than in normal hearts (27.6±4.1 μmol/g wet weight, range 20.8-36.2). Myocardial CR concentrations in six heart failure patients with plasma B-type natriuretic peptide (BNP) levels of >200 pg/ml (11.5±0.9 μmol/g wet weight, range 9.9-12.3) were significantly lower than those in four heart failure patients with plasma BNP levels of <200 pg/ml (19.8±2.5 μmol/g wet weight, range 17.7-22.9, p<0.001). Thus, our study showed that myocardial CR was decreased in non-ischemic dysfunctional hearts. Noninvasive measurements of myocardial CR by ¹H MRS may be useful in the assessment of the severity of heart failure.<br>

Journal

• Magnetic Resonance in Medical Sciences

  Magnetic Resonance in Medical Sciences 3 (1), 19-25, 2004

  Japanese Society for Magnetic Resonance in Medicine

Keywords

• ¹H magnetic resonance spectroscopy
• heart failure
• myocardium
• creatine

Details

• CRID: 1390001205195934336
• NII Article ID: 10013101242
• NII Book ID: AA11648770
• DOI: 10.2463/mrms.3.19
• ISSN: 18802206
• ISSN: 13473182
• PubMed: 16093616
• Web Site: https://www.jstage.jst.go.jp/article/mrms/3/1/3_1_19/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006205003
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed