Three cases of abdominal angina in patients with chronic renal failure: successful treatment with prostaglandin E1

• Sugiura Hidekazu

  Department of Medicine IV, Tokyo Women's Medical University

• Ogawa Tetsuya

  Department of Medicine IV, Tokyo Women's Medical University

• Hirabayashi Ayumi

  Department of Medicine IV, Tokyo Women's Medical University

• Suenaga Taeko

  Department of Medicine IV, Tokyo Women's Medical University

• Ohmae Kiyotsugu

  Department of Medicine IV, Tokyo Women's Medical University

• Nishida Eiichi

  Department of Medicine IV, Tokyo Women's Medical University

• Tsuchiya Ken

  Department of Medicine IV, Tokyo Women's Medical University

• Akiba Takashi

  Department of Medicine IV, Tokyo Women's Medical University Division of Blood Purification, Tokyo Women's Medical University

• Nihei Hiroshi

  Department of Medicine IV, Tokyo Women's Medical University

Bibliographic Information

Other Title

• 慢性腎不全に合併したａｂｄｏｍｉｎａｌ　ａｎｇｉｎａにｐｒｏｓｔａｇｌａｎｄｉｎ　Ｅ１が有効であった３症例

Abstract

We report here 3 cases of abdominal angina in patients with chronic renal failure, and they were successfully treated with intravenous administration of prostaglandin E₁ (PGE₁). Abdominal angina is a disease with a classical triad of abdominal pain after food intake, weight loss, and fear of eating due to the abdominal pain. The cause of this syndrome is mainly stricture of the main abdominal arteries and chronic intestinal ischemia. Progression of abdominal angina triggers main abdominal arterial obstruction, extensive bowel necrosis, and is sometimes fatal. In addition to its poor prognosis, the frequent appearance of abdominal pain and discomfort seriously diminishes the patient's QOL. Atherosclerosis is the cause of about 50% of the cases of stricture of the main abdominal arteries. However, chronic renal failure patients with or without dialysis who often have concomitant disease-induced atherosclerosis, might become complicated by abdominal angina. The first choice of treatment for this syndrome is usually surgical bypass or revascularization of the main arteries. However, patients with chronic renal failure possess concomitant diseases, such as obstructive arteriosclerosis, ischemic heart disease, etc., resulting in a high risk for surgical procedures. Medical treatment without any surgery may be preferable for abdominal angina, especially as a complication of chronic renal failure, however, there is still no commonly acceptable medical treatment.<br>We treated 3 cases of abdominal angina with chronic renal failure by intravenous administration of PGE₁. PGE₁ successfully reduced the degree and the frequency of patients' symptoms. These patients, who had renal failure with several complications, were not considered to be able to tolerate surgical treatment. PGE₁, which is a potent vasodilator, was effective for their symptoms. Our experience with these cases suggested that drip infusion of PGE₁ could e one of the choices for non-surgical treatment of abdominal angina as a complication in patients with chronic renal failure.

Journal

• Nihon Toseki Igakkai Zasshi

  Nihon Toseki Igakkai Zasshi 37 (4), 329-334, 2004

  The Japanese Society for Dialysis Therapy

Keywords

• abdominal angina
• prostaglandin

Details

• CRID: 1390282679652841088
• NII Article ID: 130003721837
• NII Article ID: 10013133563
• NII Book ID: AN10432053
• DOI: 10.4009/jsdt.37.329
• ISSN: 1883082X
• ISSN: 13403451
• Web Site: https://search.jamas.or.jp/link/ui/2004203049
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed