Effects of Excess Nicotinamide Administration on the Urinary Excretion of Nicotinamide N-Oxide and Nicotinuric Acid by Rats

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著者

    • Wada Hideko WADA Hideko
    • Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture
    • Sasaki Ryuzo [他] SASAKI Ryuzo
    • Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture
    • SHIBATA Katsumi
    • Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture

抄録

  We investigated a useful chemical index for an excessive nicotinamide intake and how this excessive nicotinamide intake affects the tryptophan-nicotinamide metabolism in rats. Weaning rats were fed on a tryptophan-limited and nicotinic acid-free diet containing no, 0.003%, 0.1%, 0.2%, or 0.3% nicotinamide for 21days. Urine samples were collected on the last day and analyzed the intermediates and metabolites on the tryptophan-nicotinamide pathway. Nicotinamide <I>N</I>-oxide, nicotinic acid and nicotinuric acid, metabolites of nicotinamide, were detected when nicotinamide at more than 0.1% had been taken. An intake of nicotinamide of more than 0.1% increased the urinary excretion of quinolinic acid, an intermediate on the pathway. Nicotinamide <I>N</I>-oxide and nicotinuric acid increased with increasing dietary concentration of nicotinamide. These results show that the measurements of nicotinamide <I>N</I>-oxide and nicotinuric acid in urine would be useful indices for an excessive nicotinamide intake.

収録刊行物

  • Bioscience, biotechnology, and biochemistry

    Bioscience, biotechnology, and biochemistry 68(1), 44-50, 2004-01-23

    公益社団法人 日本農芸化学会

参考文献:  43件中 1-43件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10013140724
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168451
  • NDL 記事登録ID
    6832375
  • NDL 雑誌分類
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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