Triterpene Acids from the Leaves of Perilla frutescens and Their Anti-inflammatory and Antitumor-promoting Effects

• BANNO Norihiro

  Ichimaru Pharcos Company Ltd.

• AKIHISA Toshihiro

  College of Science and Technology, Nihon University

• TOKUDA Harukuni

  Department of Biochemistry, Kyoto Prefectural University

• YASUKAWA Ken

  College of Pharmacy, Nihon University

• HIGASHIHARA Hiroshi

  Department of Biochemistry, Kyoto Prefectural University

• UKIYA Motohiko

  College of Science and Technology, Nihon University

• WATANABE Kenji

  College of Science and Technology, Nihon University

• KIMURA Yumiko

  College of Pharmacy, Nihon University

• HASEGAWA Jun-ichi

  Ichimaru Pharcos Company Ltd.

• NISHINO Hoyoku

  Department of Biochemistry, Kyoto Prefectural University

書誌事項

タイトル別名

• Triterpene Acids from the Leaves of <I>Perilla frutescens</I> and Their Anti-inflammatory and Antitumor-promoting Effects

抄録

  Nine triterpene acids, viz., six of the ursane type, ursolic acid (1), corosolic acid (2), 3-epicorosolic acid (3), pomolic acid (4), tormentic acid (5) and hyptadienic acid (6), and three of the oleanane type, oleanolic acid (7), augustic acid (8) and 3-epimaslinic acid (9), among which 1 constituted the most predominant triterpene acid, were isolated and identified from ethanol extracts of the leaves of red perilla [Perilla frutescens (L.) Britton var. acuta Kudo] and green perilla [P. frutescens (L.) Britton var. acuta Kudo forma viridis Makino]. These eight compounds, 1, 2, 4–9, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID₅₀) of 0.09–0.3 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA showed five compounds, 1–3, 5 and 9, with a potent inhibitory effect on EBV-EA induction (91–93% inhibition at 1×10³ mol ratio/TPA). Furthermore, compound 5 exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 68 (1), 85-90, 2004

  公益社団法人 日本農芸化学会

キーワード

• <I>Perilla frutescens</I>
• triterpene acid
• anti-inflammatory effect
• antitumor-promoting effect
• two-stage carcinogenesis

詳細情報

• CRID: 1390001206474583936
• NII論文ID: 10013140896
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.68.85
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 6832479
• PubMed: 14745168
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6832479
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.68.85
• Web Site: https://search.jamas.or.jp/link/ui/2004217976
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可