SMXA-5 Mouse as a Diabetic Model Susceptible to Feeding a High-fat Diet

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  • KOBAYASHI Misato
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University
  • IO Fusayo
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University
  • KAWAI Takahiro
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University
  • NISHIMURA Masahiko
    Institute for Laboratory Animal Research, Nagoya University School of Medicine
  • OHNO Tamio
    Institute for Laboratory Animal Research, Nagoya University School of Medicine
  • HORIO Fumihiko
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University

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Abstract

  The SMXA-5 strain, a new mouse model for type 2 diabetes, is a recombinant inbred strain derived from non-diabetic SM/J and A/J strains. As dietary fat is a key component in the development of diabetes, we compared the glucose tolerance and diabetes-related traits among the SMXA-5, SM/J, and A/J strains while feeding a high-fat diet for 10 weeks. SMXA-5 fed on a high-fat diet showed an increased serum insulin concentration. Judging from the hyperinsulinemia in SMXA-5, this strain showed insulin resistance, an inability of peripheral tissues to respond to insulin, which was strengthened by feeding with a high-fat diet. When fed on a high-fat diet for 5 weeks, the SMXA-5 mice showed severely impaired glucose tolerance. On the other hand, SM/J showed mildly impaired glucose tolerance, even when fed on a high-fat diet for 10 weeks. These results indicate that SMXA-5 would be available for use as a diabetic model susceptible to a high-fat diet.

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