Osteoclasts, mononuclear phagocytes, and c-Fos: new insight into osteoimmunology
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- Matsuo Koichi
- Department of Microbiology and Immunology, School of Medicine, Keio University
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- Ray Neelanjan
- Medical Scholars Program, Vanderbilt University School of Medicine
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Abstract
Osteoimmunology is the emerging concept that certain molecules link the skeletal and immune systems. The transcription factor c-Fos, a component of activator protein-1 (AP-1), is essential for osteoclast differentiation. Mice lacking c-Fos are osteopetrotic owing to impaired osteoclast development. Recent studies suggest that in contrast to this positive role in osteoclastogenesis, c-Fos expression inhibits differentiation and activation of mononuclear phagocytes. Here, we focus on the contrasting roles of c-Fos in the bone and immune lineages. Both osteoclasts and mononuclear phagocytes are derived from common myeloid precursors. Osteoclasts resorb bone, whereas macrophages and myeloid dendritic cells phagocytose microbial pathogens, initiating innate and adaptive immunity. Differentiation of the common precursors into either bone or immune lineage is determined by ligand binding to cell-surface receptors, particularly receptor activator of NF-κB (RANK) for osteoclasts, or Toll-like receptors (TLRs) for mononuclear phagocytes. Both RANK and TLRs activate the dimeric transcription factors NF-κB and AP-1. Yet, c-Fos/AP-1 plays a positive role in osteoclasts but a negative role in macrophages and dendritic cells. Further study is necessary to clarify this dual role of c-Fos.
Journal
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- The Keio Journal of Medicine
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The Keio Journal of Medicine 53 (2), 78-84, 2004
The Keio Journal of Medicine
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Keywords
Details 詳細情報について
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- CRID
- 1390282681314593536
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- NII Article ID
- 10013148286
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- NII Book ID
- AA00710216
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- COI
- 1:CAS:528:DC%2BD2cXnt1Kqs78%3D
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- ISSN
- 18801293
- 00229717
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- PubMed
- 15247511
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed