Latency and Persistence of Bovine Herpesvirus Type 4, Strain B11-41, in Bovine Nervous Tissues

この論文にアクセスする

この論文をさがす

著者

抄録

Three cattle were experimentally infected with bovine herpesvirus type 4 (BoHV-4), strain B11-41, isolated from the spinal cord of a cow, and monitored for clinical symptoms. None of them showed any clinical signs except increases of leukocyte numbers in two of them, and the body temperature remained normal throughout the experiment. Antibody titers against BoHV-4 continuously increased for one month and were maintained at a high level for more than 1 year by enzyme-linked immunosorbent assay (ELISA). The virus was isolated only from serum and peripheral blood leukocytes (PBL) of one cow in the early stage of infection, but the viral genome was detected in PBL continuously by PCR. When they were euthanized, the viral genome was detected in the lymph nodes and nervous tissues such as medulla, spinal cord, and trigeminal ganglion. These results indicate that cattle are infected with the virus latently and persistently, and the latency site would be in the tissues of the central nervous system as well as lymphoid tissues. When a seroepidemiological survey was performed on antibodies to BoHV-4 among cattle in Japan by ELISA, the rate of antibody-positive cattle was 8.9% and they were found irregularly on certain farms. <br>

収録刊行物

  • The journal of veterinary medical science

    The journal of veterinary medical science 65(1), 87-93, 2003-01-25

    公益社団法人 日本獣医学会

参考文献:  30件中 1-30件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10013227822
  • NII書誌ID(NCID)
    AA10796138
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09167250
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
ページトップへ