ｍＭＧＬ１とは異なる糖特異性を有する新規マウスマクロファージＣタイプレクチン，ｍＭＧＬ２の分子クローニングと解析

• Tsuiji Makoto

  Laboratory of Molecular Immunology, The Rockefeller University

書誌事項

タイトル別名

• Molecular Cloning and Characterization of a Novel Mouse Macrophage C-type Lectin, mMGL2, Which Has a Distinct Carbohydrate Specificity from mMGL1.
• mMGL1 トワ コトナル トウ トクイセイ オ ユウスル シンキ マウスマクロファージ Cタイプレクチン mMGL2 ノ ブンシ クローニング ト カイセキ ガン エイブン

抄録

Protein-carbohydrate interactions serve a variety of functions in the immune system. A number of lectins mediate both pathogen recognition and cell-to-cell interactions using structurally related carbohydrate recognition domains (CRDs).<br>Macrophage galactose-type C-type lectin (MGL) was previously believed to be derived from a single gene. However, we describe the properties of another novel MΦ galactose-type C-type lectin, mMGL2. As an obvious consequence, the previous mMGL must now be called mMGL1. These lectins are highly homologous to each other except in their cytoplasmic domains and CRDs. The mMGL2 mRNA was also detected in mMGL1-positive cells. We found that mMGL2 has distinct carbohydrate specificity from mMGL1. These two lectins may function cooperatively as recognition and endocytic molecules on macrophages and bone marrow-derived immature dendritic cells.

収録刊行物

• Ｔｒｅｎｄｓ　ｉｎ　Ｇｌｙｃｏｓｃｉｅｎｃｅ　ａｎｄ　Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ

  Ｔｒｅｎｄｓ　ｉｎ　Ｇｌｙｃｏｓｃｉｅｎｃｅ　ａｎｄ　Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ 15 (83), 153-157, 2003

  FCCA(Forum: Carbohydrates Coming of Age)

キーワード

• Galactose-type C-type lectin
• Lewis X antigen
• Tn antigen
• Macrophage
• Immature dendritic cell

詳細情報

• CRID: 1390001204369296384
• NII論文ID: 10013241170
• NII論文ID: 50000270038
• NII書誌ID: AA10995236
• DOI: 10.4052/tigg.15.153
• ISSN: 18832113
• ISSN: 09157352
• NDL書誌ID: 6651422
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6651422
• Web Site: https://search.jamas.or.jp/link/ui/2004013194
• 本文言語コード: ja
• データソース種別:
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