Population Pharmacokinetic Analysis of Trastuzumab using the Mixed-Effect Modeling Function-NLME
Nonlinear Mixed-Effects Methods for S-PLUS (Mixed-effects modeling function-version 3.3 NLME) have been reported. A zero-order infusion model was created for NLME in this study. Data from the literature for trastuzumab were used for analysis with the zero-order infusion model for NLME ; data for single as well as multiple administration (1 q per week) studies were available for doses of 1, 2, 4 and mg/kg.<BR>The two-compartment model was better than the one-compartment model in describing the dispositionof trastuzumab, for both single and multiple administration. In single-dose fitting, the predicted concentrations agreed well with the observed concentrations in the one-compartment model as well as in the twocompartment model. However, in multiple-dose fitting, the predicted concentrations slightly underestimated the observed concentrations at higher doses; this was considered evidence of the nonlinear pharmacokinetics of trastuzumab or a problem with the estimation of half-life.
- 臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 33(4), 117-126, 2002-07-31
The Japanese Society of Clinical Pharmacology and Therapeutics