Population Pharmacokinetic Analysis of Trastuzumab using the Mixed-Effect Modeling Function-NLME

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著者

    • FUNAKI Tomoo
    • 日本ロシュ株式会社医薬開発本部臨床薬理グループ Clinical Pharmacology Group, Nippon Roche K. K.
    • SHIOMI Mari
    • 日本ロシュ株式会社医薬開発本部臨床薬理グループ Clinical Pharmacology Group, Nippon Roche K. K.

抄録

Nonlinear Mixed-Effects Methods for S-PLUS (Mixed-effects modeling function-version 3.3 NLME) have been reported. A zero-order infusion model was created for NLME in this study. Data from the literature for trastuzumab were used for analysis with the zero-order infusion model for NLME ; data for single as well as multiple administration (1 q per week) studies were available for doses of 1, 2, 4 and mg/kg.<BR>The two-compartment model was better than the one-compartment model in describing the dispositionof trastuzumab, for both single and multiple administration. In single-dose fitting, the predicted concentrations agreed well with the observed concentrations in the one-compartment model as well as in the twocompartment model. However, in multiple-dose fitting, the predicted concentrations slightly underestimated the observed concentrations at higher doses; this was considered evidence of the nonlinear pharmacokinetics of trastuzumab or a problem with the estimation of half-life.

収録刊行物

  • 臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

    臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 33(4), 117-126, 2002-07-31

    一般社団法人 日本臨床薬理学会

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各種コード

  • NII論文ID(NAID)
    10013250160
  • NII書誌ID(NCID)
    AN0025404X
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03881601
  • データ提供元
    CJP書誌  J-STAGE 
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