Interaction Between Digoxin and Calcium Channel Blockers in Patients Undergoing Hemodialysis

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著者

    • UENISHI Koji
    • 特定医療法人仁真会白鷺病院薬剤科 Department of Pharmacy Services, Shirasagi Hospital
    • HIRATA Sumio
    • 特定医療法人仁真会白鷺病院薬剤科 Department of Pharmacy Services, Shirasagi Hospital
    • IZUMI Satoshi
    • 特定医療法人仁真会白鷺病院薬剤科 Department of Pharmacy Services, Shirasagi Hospital
    • FURUKUBO Taku
    • 特定医療法人仁真会白鷺病院薬剤科 Department of Pharmacy Services, Shirasagi Hospital
    • OTA Miyuki
    • 特定医療法人仁真会白鷺病院薬剤科 Department of Pharmacy Services, Shirasagi Hospital
    • FUJITA Minori
    • 特定医療法人仁真会白鷺病院薬剤科 Department of Pharmacy Services, Shirasagi Hospital
    • IZUMOTANI Tsuyoshi
    • 特定医療法人仁真会白鷺病院診療部 Department of Internal Medicine, Shirasagi Hospital
    • YAMAKAWA Tomoyuki
    • 特定医療法人仁真会白鷺病院診療部 Department of Internal Medicine, Shirasagi Hospital
    • TANAKA Kazuhiko
    • 大阪薬科大学臨床薬剤学 Department of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences

抄録

Calcium channel blockers are often co-administered with digoxin because of a high frequency of hypertension and cardiac arrhythmia in patients undergoing hemodialysis. There have been several reports about the interactions between calcium channel blockers and digoxin mediated by P-glycoprotein in subjects with normal renal function, but few reports in patients undergoing hemodialysis. In this report, the interactions between digoxin and calcium channel blockers in patients undergoing hemodialysis were investigated. The serum digoxin concentration/digoxin dosage per week per body weight ratio (C/D ratio) was calculated, and the C/D ratio before and after co-administration of Ca channel blockers (verapamil, nifedipine, amlodipine) was compared. The rate of change in C/D ratio of digoxin was calculated, and the relationship between the rate of change in the C/D ratio of digoxin and the dose of Ca channel blocker per body weight was investigated. The C/D ratio of digoxin was significantly higher after co-administration of verapamil than that without verapamil (P<0.05), but there was no significant difference between co-administration of nifedipine or amlodipine and without co-administration. There was a significant correlation between the rate of change in the C/D ratio of digoxin before and after co-administration of verapamil and the dose of verapamil per body weight (r=0.909, P<0.001). It was suggested that the magnitude of the drug interaction between digoxin and verapamil was dependent on the verapamil dose per body weight.<BR>Based on these results, when a high dose of verapamil is co-administered, it appears that adequate precautions are needed regarding digoxin intoxication even in patients undergoing hemodialysis.

収録刊行物

  • 臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

    臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 34(6), 323-328, 2003-11-30

    一般社団法人 日本臨床薬理学会

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各種コード

  • NII論文ID(NAID)
    10013250319
  • NII書誌ID(NCID)
    AN0025404X
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03881601
  • データ提供元
    CJP書誌  J-STAGE 
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